Protein Alignment nAChRalpha2 and lgc-5

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_501411.4
• Gene: lgc-5 / 184620
• WormBaseID: WBGene00017543
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 390
• Identity: 86/390 - (22%)
• Similarity: 180/390 - (46%)
• Gaps: 61/390 - (15%)

  Fly    63 VSNNTDTVLVKLGLRLSQLIDLNLK--------------------DQILTTNVWLEH---EWQDH 104
            |.:||:.:|.:|   .::..|:|:|                    ||...|.::.:.   :|.|.
 Worm    24 VESNTEVLLQEL---FNRTYDVNVKPSDTLTTVTITPNTFLLLSMDQTQETILFSQEFLLKWYDP 85

  Fly   105 KFKWDPSEYGGVTE-LYVPSEHIWLPDIVLYNNADGEYVV-TTMTKAILHYTGKVVWTPPAIFKS 167
            ...|:.:.:....| :.:....:|:||::.......|.:: ..|..|.|.|.|::..:.||:..:
 Worm    86 ILHWNRTLFDYNREWIKISVSRVWVPDVIFTKRLSVESLLDEDMQMADLRYNGEIRTSLPAVVST 150

  Fly   168 SCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLR-EYYPSVEWDILG 231
            ||.::::.||.|.|.|.:..|||.:|...|.::         :.|:..:.|| .:..:.||::|.
 Worm   151 SCPLNIQDFPHDVQECNISMGSWAFDRTVIVVQ---------SSVDEILPLRGRFEGNSEWELLS 206

  Fly   232 VPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGE----- 291
            :.|.|.:.:.......:.:|.:.:||:||.::|.:.:..|...:..:::...:.| :|.|
 Worm   207 IRAFRTDSFEYSLGTSFSEITYTVTLQRKPVYYVLVIQAPTFILCTITIFGLFSP-NSNENERLS 270

  Fly   292 KIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTH 356
            ::.||:::..:.:|...|:|:::|..| .|||||.|::..:.:|..:.:..|:|.::|:...:..
 Worm   271 RVELCLNMFAAISMMLQLVSDMMPKAS-RLPLLGNYIIAEIFVVTAATIAAIVIQHVHHHVHTNA 334

  Fly   357 KMRP-WIRSF---------FIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQ 411
            ...| |:|..         |..:...:..|.||::::..::.      ||.|..|....:.|.:|
 Worm   335 TCPPKWLRCLVLCDCMREEFPSKTSSVSSMDVPENIIAPVSL------LKSSLHKTAFLVRDTLQ 393

  Fly   412  411
             Worm   394  393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	51/225 (23%)
		LIC	47..544	CDD:273305	86/390 (22%)
lgc-5	NP_501411.4	LGIC_ECD_cation	51..235	CDD:349790	41/192 (21%)
		LGIC_TM	238..>323	CDD:365787	20/86 (23%)
		TM1 helix	238..261	CDD:349850	2/22 (9%)
		TM2 helix	273..294	CDD:349850	5/20 (25%)
		TM3 helix	304..323	CDD:349850	3/18 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810