Protein Alignment nAChRalpha2 and lgc-22

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001255259.1
• Gene: lgc-22 / 184533
• WormBaseID: WBGene00017483
• Length: 445
• Species: Caenorhabditis elegans
• Alignment Length: 376
• Identity: 78/376 - (20%)
• Similarity: 142/376 - (37%)
• Gaps: 69/376 - (18%)

  Fly     2 APGCCTTRPRPIALLAHIW--RHCKPLCLLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVS 64
            |.|.|.|..        :|  .:|:.         .|.:.|....|.:|...:.:.|.   ....
 Worm    36 ATGECATNA--------VWMMANCRK---------SCHSCQGGDRAWKLRTHIQTTYQ---NATD 80

  Fly    65 NNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLP 129
            |.|..|.|: .:|::. ::::.:.|.:.........|.|....||..:: |::.|......||.|
 Worm    81 NKTKVVRVE-SVRINN-VEIDERRQNVKVFGRFVLSWNDTMVSWDKEQW-GLSWLNFYWIQIWTP 142

  Fly   130 DIVLYNNADGEYVVTTMTKAI-LHYTGKV-VWTPPAIFKSSCEIDVRY--FPFDQQTCFMKFGSW 190
            :||..|...........:|.: .:|||:: :|:.   |..:.....:|  :|.|.|....||
 Worm   143 NIVQINGGSTSNPGQVTSKVLAANYTGQIYLWSD---FSFTTPFRFQYEDYPNDMQRVCYKF--- 201

  Fly   191 TYDGDQIDLKHISQKNDKDNKV-EIGIDLREYYPSVE-WDILGVP------------AERHEKYY 241
              |..::...|.:......||. |...|     |.|. |.|..|.            ..::....
 Worm   202 --DDKRLMAVHFTVAEGVKNKEREATTD-----PFVSGWKIEDVEVVSITHSPDNGGTGKNGLES 259

  Fly   242 PCCAEPYPDIFFN------------ITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIA 294
            |...|...|...|            |:|||..:::|..:::|.:..|..::...:......:.|.
 Worm   260 PYTVEQLSDPRRNPFDVQADNGELCISLRRNAVYFTAEMLLPALITSLFTLAAVFFQLSKTQPIL 324

  Fly   295 LCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIII 345
            |..|: ::|.:..:|:|:.:||.:...|.:.||..|.|....:..||::::
 Worm   325 LGFSV-VAQILSLILVSQRLPSFTAHTPTILKYAGFNMTWTAILFVISLVL 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	52/248 (21%)
		LIC	47..544	CDD:273305	69/329 (21%)
lgc-22	NP_001255259.1	ShKT	24..58	CDD:214586	7/38 (18%)
		LGIC_ECD	85..249	CDD:355788	39/179 (22%)
		Cys-loop	183..198	CDD:349787	4/14 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910