Protein Alignment nAChRalpha2 and lgc-23

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_510016.2
• Gene: lgc-23 / 182622
• WormBaseID: WBGene00007594
• Length: 403
• Species: Caenorhabditis elegans
• Alignment Length: 428
• Identity: 93/428 - (21%)
• Similarity: 170/428 - (39%)
• Gaps: 86/428 - (20%)

  Fly    30 LVLLLLCETV--------------QANPDAKRLYDDLLSNYNRLIRPVSNNTDT---VLVKLGLR 77
            |::|:|..|:              ||..|.::|.:|:|.       |:..:..:   |.:...|:
 Worm     5 LMILVLFNTIPIRVSEADEESERHQAYLDHRKLKEDVLG-------PLDGSMPSELPVFIGAQLK 62

  Fly    78 LSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTE---------LYVPSEHIWLPDIVL 133
            |..:..::.|...||..:.::..|.|.:.:||||.|.|.|.         ||    .||.|.|.:
 Worm    63 LDHISRVDEKTGFLTLALTVKFMWSDERLQWDPSHYSGFTRTRLEFVDFWLY----QIWKPRIYM 123

  Fly   134 YNNADG------EYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKF----- 187
            .|..:.      :.:..|:.:..:|..|.|:.|...:.|:.|.:|.:.:|.|.|.|...|
 Worm   124 TNTYERRQSKTIDLLSNTLVEMDIHSKGFVMTTTKILLKTFCFLDFKGYPHDFQNCSFSFIPNMN 188

  Fly   188 ------GS----WTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPS-VEWDILGVPAERHEKYY 241
                  ||    ..:..|..|.:.:.:..|......:..||..:... |..|:...|......:
 Worm   189 ANDIFLGSSMLKAKFTKDFTDPQQVVRVQDFQINDVVTEDLYLFMNRIVLHDLTREPRSLVRSF- 252

  Fly   242 PCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIALCISILLSQTMF 306
                     :.|.|.|:||.::..:.|..|.:.|....::..:||::..  :.|.:..|:|:.::
 Worm   253 ---------VSFTIVLQRKNVYVHLQLYAPMIFICTCLIISGFLPSEYA--LPLLVFNLISEYLY 306

  Fly   307 FLLISEIIPSTSLALPLLGKYLLF----TMLLVGLSVVITIIILNIHYRKPSTHKMR----PWIR 363
            |..|.:::|:.....|.:.....|    ||.::|..    :.|:.|..:|...:.:.    |...
 Worm   307 FHNIKDVLPTDFDGTPTIALIATFTLAETMSIIGWK----MFIITIMTKKQKAYFLNSSKFPLDS 367

  Fly   364 SFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTK 401
            .||..|:.:.|| .:.|.|:..|.|.  ::|..|...|
 Worm   368 GFFNIRVLRRLL-TIDKFLMYMLIAQ--SFGSIFIMLK 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	55/252 (22%)
		LIC	47..544	CDD:273305	86/397 (22%)
lgc-23	NP_510016.2	Neur_chan_LBD	34..262	CDD:367255	52/248 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810