DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha2 and lgc-25

DIOPT Version :9

Sequence 1:NP_524482.1 Gene:nAChRalpha2 / 42919 FlyBaseID:FBgn0000039 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_510359.3 Gene:lgc-25 / 181525 WormBaseID:WBGene00010994 Length:502 Species:Caenorhabditis elegans


Alignment Length:540 Identity:121/540 - (22%)
Similarity:220/540 - (40%) Gaps:121/540 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 LLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQL--IDLNLKDQIL 91
            :||:..|...|......::|...|:..||..:|||.:......|.:.|.::.:  :|.:.:..::
 Worm    11 ILVIWHLDNQVCGLSKEQQLEKQLMVKYNYKVRPVKSEATVTQVNVFLSIAHVEKVDEHEQTALV 75

  Fly    92 TTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGE--YVVTTMTKAILHYT 154
            ..::|.  .|.|...:|| ::...||:|.:.:..:|.|.:.|||:|.|.  ::......|.::.|
 Worm    76 HGHIWA--TWIDEYMQWD-AKKENVTKLTISAHSLWQPALALYNSARGNSWHLYMGAMPATVYST 137

  Fly   155 GKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLK--HISQKNDKDNKVEIGID 217
            |||..|....|..:|:.|...:|||||:|.:....|.|:.:|::|.  :|.::..|.:       
 Worm   138 GKVWSTGTFSFYVTCQFDFTNWPFDQQSCPIVIADWVYNLNQVNLSDPYILKEYGKPS------- 195

  Fly   218 LREYYPSVE---------WDILGVPAERHEKYYP-CCAEPYPD---------IFFNITLRRKTLF 263
            :|..|..:|         |:::.. .::|..:.| .|.|..|:         :.|.|.|||...:
 Worm   196 IRLSYDPIEKSDKRHVAGWEVMDA-WKKHCYWGPKGCKEEQPEGEAEWYWSLLEFGIILRRHLPY 259

  Fly   264 YTVNLIIPCVGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGK-- 326
            ::::::.|..|.|.:.:|.|::     |..::|         ||.::..||..:.....||.|  
 Worm   260 FSLSILFPMAGTSLILLLCFWI-----ETHSIC---------FFTIMLNIILQSYYGSSLLAKMP 310

  Fly   327 ---------YLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDL 382
                     ..|:.|.|:..:|...:|:.:                .|...||||...:.:..|:
 Worm   311 PGSGRTPKIVHLYNMNLLLSAVQFVLIVFS----------------EFLRLRLPKKFELDLGFDI 359

  Fly   383 L---RDLAANKI--NYGLKFSKTK-----FGQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGM 437
            :   :....:|:  ..||.|...:     :....::|:....||||..|       ||.|  |.:
 Worm   360 IGVPQRFGVDKLFTQKGLSFDPQELFSNVYSTRTLEEILEQGGGSSSTS-------VGIG--NPL 415

  Fly   438 H-------------------VTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDDS-LSDVAA 482
            |                   :|:....||.....|   ||:....|....:....::. :.||..
 Worm   416 HEDITSFQKSSDSSVLIDIPMTSEPQSFSASTSEL---LSSEPSSNEETQISEEPEEERILDVQL 477

  Fly   483 R--KKYPFELEKAIHNVMFI 500
            |  |:|.|.|...||.:.|:
 Worm   478 RHIKRYVFCLVIFIHIIAFL 497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha2NP_524482.1 LGIC_ECD_nAChR_proto_alpha-like 44..263 CDD:349832 60/243 (25%)
LIC 47..544 CDD:273305 117/522 (22%)
lgc-25NP_510359.3 LGIC_ECD_cation 52..256 CDD:349790 52/214 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.910

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