DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and acr-12

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_510262.1	Gene:	acr-12 / 181475	WormBaseID:	WBGene00000051	Length:	573	Species:	Caenorhabditis elegans

Alignment Length:	555	Identity:	216/555 - (38%)
Similarity:	310/555 - (55%)	Gaps:	82/555 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPS 111
            :||:|||.:||::.|||.|::|.:.|.:|..|.::||::.|:|:||||:|||.:|.|.|..|.|.
Worm    40 QLYEDLLFDYNKVPRPVKNSSDILTVDVGASLIRIIDVDEKNQVLTTNLWLEMKWNDAKLTWTPE 104

  Fly   112 EYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYF 176
            :|||:..|::||:.||.||:||||||.|:..:|.:|.|::.:.|.|.|.||||:||.|.|||.:|
Worm   105 KYGGLKTLHIPSDFIWTPDLVLYNNAAGDPDITILTDALVTFEGNVYWQPPAIYKSFCPIDVTWF 169

  Fly   177 PFDQQTCFMKFGSWTYDGDQIDLKHISQK-----NDKDNKVEI---GIDLREYYPSVEWDILGVP 233
            |:|.|.|.||||:|||.|..:|||.:.|:     ...||.||.   |:||..:|.|.|||:|.:.
Worm   170 PYDSQKCEMKFGTWTYTGRYVDLKQLPQEEVVTITKDDNDVEFMQQGMDLSFFYRSAEWDLLSLT 234

  Fly   234 AERHEKYYPCCAEP--YPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIALC 296
            :|||...|..|..|  |.||.:...|||||||:|.|||:||..||.|:..||||   |..||...
Worm   235 SERHSVLYASCCGPEKYVDITYYFGLRRKTLFFTCNLILPCFLISILTTFVFYL---SDHKITFS 296

  Fly   297 ISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPW 361
            ||||::.|:|||::.:::|.|||.:|:.|:||:.||:||.||.|:::|.:|..:|..|.|||.||
Worm   297 ISILVTLTVFFLVLIDLMPPTSLVIPMFGRYLITTMILVALSTVVSVITVNFRFRSGSAHKMSPW 361

  Fly   362 IRSFFIKRLPKLLLMRVPK----------------------------DLLRDLAANKINYGLKFS 398
            ||:.|:|.|||:|||..|:                            :..|:.|..|.|..:...
Worm   362 IRAVFLKFLPKILLMSRPEKGEVTKQPPLVNAASLVGSNYATAAKAANEYRNKAKGKNNDLMSLR 426

  Fly   399 KTKFGQALMD---EMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTL 460
            .....||:::   :|:|.:..|                       |..||....:.|......|:
Worm   427 GKPSSQAVLNNTFDMRMRNNDS-----------------------TVENRLKPYLCAQNNNAPTV 468

  Fly   461 SGYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAE-DQDWGFVAMVM 524
            :...........:||.:            ....::.|.||..|. |.:|...| ..||.|||||:
Worm   469 AFRKTKRQKSKSVDDVV------------FMNLLNQVRFIAEHF-RHNELEGEISDDWTFVAMVL 520

  Fly   525 DRLFLWLFMIASLVGTFVILGEAPSLYDDTKAIDV 559
            |||||.:|.:.: |||..|:.|:|||||.:|.:::
Worm   521 DRLFLIIFSVLN-VGTVFIILESPSLYDYSKPMNI 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	108/225 (48%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	208/538 (39%)
acr-12	NP_510262.1	LIC	14..539	CDD:273305	208/538 (39%)
		Neur_chan_LBD	38..264	CDD:280998	106/223 (48%)
		Neur_chan_memb	271..538	CDD:280999	96/306 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3454
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.870