Protein Alignment nAChRalpha2 and acr-2

DIOPT Version :10

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_509128.1
• Gene: acr-2 / 180936
• WormBaseID: WBGene00000042
• Length: 575
• Species: Caenorhabditis elegans
• Alignment Length: 548
• Identity: 197/548 - (35%)
• Similarity: 305/548 - (55%)
• Gaps: 70/548 - (12%)

  Fly    44 DAKRLYDDLLSNYNRLIRPVSN-NTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFK 107
            |..||..||...||.|||||.| ::..|:|..|:.:..||:::.|:|||.|||||..:|.|.:..
 Worm    59 DEDRLVIDLFREYNFLIRPVKNVSSPPVVVDFGVAMILLINVDEKNQILQTNVWLTMKWNDFQLA 123

  Fly   108 WDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSCEID 172
            |:|:|||.::.|:|||:.:|||||||:|||||.|.|:..:...:.:.|.|.|.|||:|||||.||
 Worm   124 WNPAEYGNISNLHVPSDRVWLPDIVLFNNADGNYEVSFKSNVFVDHHGDVTWVPPAMFKSSCRID 188

  Fly   173 VRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERH 237
            |.:||||:|.|.:.||||||:.:::.|...       |.:: .:.|.:|..|..||::.||.:..
 Worm   189 VEWFPFDEQCCTLVFGSWTYNSEEVRLHWY-------NNIQ-AVQLHDYSYSGIWDVIDVPGQLV 245

  Fly   238 EKYYPCCAEPYPDI-----FFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIALCI 297
            .|         ||:     .||:.:|||||||||.||||.|.:::|||:.||||.|||||::|.|
 Worm   246 HK---------PDLKENKMVFNVVIRRKTLFYTVILIIPTVLMAFLSVMAFYLPVDSGEKVSLTI 301

  Fly   298 SILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWI 362
            |:||:..:|.||:|:|:|.|| .:||:|||||...:|...:||.|::|:||::|...:|||..|:
 Worm   302 SLLLALVVFLLLVSKILPPTS-NIPLMGKYLLLAFVLNITAVVGTVVIVNIYFRSALSHKMPTWV 365

  Fly   363 RSFFIKRLPKLLLMRVPKDL-------LRDLAANKINYGLKFSKTKFGQALMDEMQMNSGGSSPD 420
            |..|::.||.||:|:.|:.:       :.:..|::| :............::..:|:.:...:..
 Worm   366 RKVFLEFLPHLLVMKRPERIPIFNGYFVEEYCASEI-FDASLVMPSMTATMLPFLQVTTNLKAAS 429

  Fly   421 SLRRMQGRVGAGGCN----GMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSLSDV- 480
            |....|.......|:    .:.:..:..|                      :..:.|||...|:
 Worm   430 STSSGQSSEHHENCSKWKKRLSIRMSKRR----------------------APRARLDDDSEDII 472

  Fly   481 ---------AARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIAS 536
                     :.::|...|::..:..:.:|..||:|:........||.:||||:|||.|.:|...:
 Worm   473 DDTNGNHVDSLQEKISKEMKTTVEAIAYIAEHMKREMSLKKMRDDWKYVAMVLDRLILLIFFGVT 537

  Fly   537 LVGTFVILGEAPSLYD--DTKAIDVQLS 562
            |.||..|:..||.::|  |.:||..:|:
 Worm   538 LGGTLGIICSAPHVFDFVDQEAIISKLN 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	96/224 (43%)
		LIC	47..544	CDD:455710	188/523 (36%)
		Cys-loop	169..183	CDD:349832	9/13 (69%)
acr-2	NP_509128.1	LIC	54..544	CDD:455710	189/525 (36%)
		LGIC_ECD_nAChR_proto_beta-like	59..265	CDD:349833	94/222 (42%)
		Cys-loop	185..199	CDD:349833	9/13 (69%)