DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and lev-1

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001255705.1	Gene:	lev-1 / 178269	WormBaseID:	WBGene00002974	Length:	507	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	203/554 - (36%)
Similarity:	305/554 - (55%)	Gaps:	107/554 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 CETVQANPDAKRLYDDLLSNYNRLIRPVSNNTD-TVLVKLGLRLSQLIDLNLKDQILTTNVWLEH 99
            ||.:.|.   .||..||...||.|::||.|.:: .::||:|::|..||:::.|:|::.|||||..
Worm    32 CEDIDAE---DRLMVDLFRGYNSLVQPVRNRSELPMIVKIGMQLVLLINVDEKEQVMHTNVWLTM 93

  Fly   100 EWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGKVVWTPPAI 164
            :|.|.:.||||.:|..:|::.|..|.:|||||||:|||||.|.|:.|...::..||.|:|.||||
Worm    94 KWDDFQLKWDPRDYANITQIRVAPEKVWLPDIVLFNNADGNYEVSFMCNVLILSTGTVLWVPPAI 158

  Fly   165 FKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDI 229
            :||||.|||.:||||.|.|.:.||||||:.|:|.|..::  :|:       :|..||..|..||:
Worm   159 YKSSCIIDVEFFPFDDQLCSLTFGSWTYNRDEIKLDFLT--SDR-------VDFSEYSTSSIWDM 214

  Fly   230 LGVPA----ERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSG 290
            :..||    :|..            |.|.|.:|||||||||.||:|.|.:::|:|.|||||..||
Worm   215 MDGPAVLTSDRSR------------IEFQIRIRRKTLFYTVVLILPTVLMAFLNVTVFYLPTASG 267

  Fly   291 EKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPST 355
            ||:.|.:::|||..:|.||:|:|:|.||.::||:.||||.|.:|..:::::|.||.||::|.|.|
Worm   268 EKMGLTMNVLLSIVVFLLLVSKILPPTSSSIPLVAKYLLLTFVLNIITIMVTTIICNIYFRSPIT 332

  Fly   356 HKMRPWIRSFFIKRLPKLLLMRVP--KDLLRDLAANKINYGLKFSKTKFGQALMDEMQMNSGGSS 418
            |::.||:|..|:..||.|:.|:.|  |::::......:..|          ..::|..|.||...
Worm   333 HRLPPWVRKVFLDILPLLMCMQRPHRKNVIQRSHRRLLETG----------PSVEENPMRSGEHH 387

  Fly   419 P--------DSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDD 475
            |        ||.||:  |:.:                                       ..|||
Worm   388 PLCRHTHNQDSCRRV--RIQS---------------------------------------DELDD 411

  Fly   476 SLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAE-DQDWGFVAMVMDRLFLWLFMIASLVG 539
            .||.         |.::||..:.||..: :|.:|...: ..||.|:|.|:||..|:.|..|::.|
Worm   412 ELSP---------EAQRAIDAIEFITEN-RRDEEITKQFRDDWKFIASVVDRFLLYGFFGATVGG 466

  Fly   540 TFVILGEAPSLYD--DTKAIDVQLSDVAKQIYNL 571
            |..|:..|||:::  |..|..|:|    ||:|::
Worm   467 TIGIIFTAPSVFETFDENATLVKL----KQLYDM 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	95/223 (43%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	189/512 (37%)
lev-1	NP_001255705.1	LIC	15..474	CDD:273305	193/526 (37%)
		Neur_chan_LBD	38..238	CDD:280998	93/223 (42%)
		Neur_chan_memb	245..470	CDD:280999	89/285 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920