Protein Alignment nAChRalpha2 and cup-4

DIOPT Version :10

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_498710.2
• Gene: cup-4 / 176104
• WormBaseID: WBGene00000845
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 393
• Identity: 70/393 - (17%)
• Similarity: 142/393 - (36%)
• Gaps: 94/393 - (23%)

  Fly    26 LCLLLVLLLLCETVQANP----------DAKRLYD------------DLLSNYNRLIRPVSNNTD 68
            :|.:|:..|..:....|.          ||:..::            .:...||...||:.|.:.
 Worm     7 VCFILIFYLPIQKKHVNSQQQGIDSDDGDAESFFNKSYSEHQSALEQKIFRGYNPKNRPMKNASF 71

  Fly    69 TVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVL 133
            ..:|.:...:.. :.:|.::|.:|.:..:...|.|....|||.::..:....|....:|.|.|.:
 Worm    72 PTIVDVHWHIIH-VSINQREQTMTVHGHIYMRWFDEFLVWDPKDFNNIQYARVKKWQVWQPKIKV 135

  Fly   134 YNNADG---EYVVTTMTKAILHYTG----KVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWT 191
            .|:|.|   .:..:|....|:...|    ||...|....|..|..|...:|:|...|.:...|.:
 Worm   136 SNSASGLGSAFDFSTSAHVIIQMMGKDRAKVEMYPTFSIKVGCAFDFTDYPYDLNKCAINLFSTS 200

  Fly   192 YDGDQIDLKHI------------SQKNDK---DNKVE--------------------IGIDLREY 221
            ...| :.|:::            .||..:   |.|::                    .|.||
 Worm   201 TMAD-VQLQNLYAIPPTLSFGWEEQKMKRIISDFKIQNVSSSALYYTNGNITSSAPITGFDL--- 261

  Fly   222 YPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLP 286
              ...|.:|.|                     .::..|.:..:...::.||:.::.|..:.|::.
 Worm   262 --GSTWSMLAV---------------------TVSFVRHSPLFEAAVVTPCIVVASLISMTFFID 303

  Fly   287 ADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVI-TIIILNIHY 350
            :.|...:.:.:...: |.:|...:.|.:|.:...:|...|.:...|...||::|: :.::...:|
 Worm   304 SLSSTFLLMMLHFYV-QLIFLHDLVEKLPLSVSEIPFCIKLIGILMYTNGLTLVLHSSLLCGSYY 367

  Fly   351 RKP 353
            :.|
 Worm   368 KCP 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	49/272 (18%)
		LIC	47..544	CDD:455710	64/362 (18%)
		Cys-loop	169..183	CDD:349832	4/13 (31%)
cup-4	NP_498710.2	LGIC_ECD_cation	73..246	CDD:349790	35/174 (20%)
		Cys-loop	178..192	CDD:349790	4/13 (31%)