Protein Alignment nAChRalpha2 and unc-29

DIOPT Version :10

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_492399.1
• Gene: unc-29 / 172703
• WormBaseID: WBGene00006765
• Length: 493
• Species: Caenorhabditis elegans
• Alignment Length: 556
• Identity: 201/556 - (36%)
• Similarity: 316/556 - (56%)
• Gaps: 96/556 - (17%)

  Fly    29 LLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTD-TVLVKLGLRLSQLIDLNLKDQILT 92
            :::.|::..|:.|:.|.:||..|:...||.||:||.|::: .::||:.|:|..||:::.|||::.
 Worm    14 VVIFLVIINTINASDDEERLMVDVFRGYNSLIQPVRNSSELPLIVKMALQLVLLINVDEKDQVMH 78

  Fly    93 TNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGKV 157
            |||||..:|.|.:.||:|..||.:.::.|..:.:|||||||:|||||.|.|:.|...::::.|.:
 Worm    79 TNVWLTLQWHDFQMKWNPVNYGEIKQIRVSPDKVWLPDIVLFNNADGNYEVSFMCNVVINHKGDM 143

  Fly   158 VWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYY 222
            :|.||||:||||.|||.:||||:|.|.:.||||||:.::|.|:.:        :.|: :|:.||.
 Worm   144 LWVPPAIYKSSCIIDVEFFPFDEQVCTLVFGSWTYNENEIKLEFV--------QAEL-VDVSEYS 199

  Fly   223 PSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPA 287
            .|..||::.|||....|        ...|.|.:.:|||||||||.||||.|.:::||:.||:||.
 Worm   200 ASSIWDVIDVPASLVNK--------RSRIEFQVRIRRKTLFYTVVLIIPTVLMAFLSMAVFFLPT 256

  Fly   288 DSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRK 352
            ||||||.|.||:|||..:|.||:|:|:|.||..:||:.||||.|.:|..:::::|:||:|:::|.
 Worm   257 DSGEKITLTISVLLSIVVFLLLVSKILPPTSSTIPLMAKYLLLTFVLNVITILVTVIIINVYFRG 321

  Fly   353 PSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQMNSGGS 417
            |.||:|..|:|..|::.||||:.|:.||                                  ..|
 Worm   322 PRTHRMPQWVRVVFLQFLPKLVCMKRPK----------------------------------SAS 352

  Fly   418 SPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPS----VLSGLDD--- 475
            ...::|                       ||:....|.|..|||     ||    :....||
 Worm   353 ERSAVR-----------------------SGMAQLPGVGQFTLS-----PSAHHPLCPSADDRTT 389

  Fly   476 SLSDVAARKK---YPFELE--KAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIA 535
            ::.:.|:.:.   ||...:  :||..:.:|..|::|.::..:...||.:|||::|||.|::|...
 Worm   390 TIRNTASNETSAYYPLSTDALRAIDAIEYITEHLKRDEQHKSFRDDWKYVAMIIDRLLLYVFFGI 454

  Fly   536 SLVGTFVILGEAPSLYDDTKAIDVQ-LSDVAKQIYN 570
            ::.||..||..||.::   :.||.| :.|..|:.|:
 Worm   455 TVGGTCGILFSAPHVF---QRIDQQEMLDRLKEKYD 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	92/219 (42%)
		LIC	47..544	CDD:455710	187/509 (37%)
		Cys-loop	169..183	CDD:349832	9/13 (69%)
unc-29	NP_492399.1	LIC	6..466	CDD:455710	193/530 (36%)
		LGIC_ECD_nAChR_proto_beta-like	29..230	CDD:349833	90/217 (41%)
		Cys-loop	155..169	CDD:349833	9/13 (69%)