DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and unc-63

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_491533.2	Gene:	unc-63 / 172150	WormBaseID:	WBGene00006797	Length:	502	Species:	Caenorhabditis elegans

Alignment Length:	545	Identity:	264/545 - (48%)
Similarity:	346/545 - (63%)	Gaps:	70/545 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTT 93
            :|:.|||.....||.||.||::||:::||:|:||||.|.:|::|...|:||||:|::.|:||:||
Worm    11 ILIFLLLSPPTHANRDANRLFEDLIADYNKLVRPVSENGETLVVTFKLKLSQLLDVHEKNQIMTT 75

  Fly    94 NVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGKVV 158
            ||||:|.|.|:|.:|||.|||||..|||||:.|||||:||||||||.|.||.||||.|.|.|.|.
Worm    76 NVWLQHSWMDYKLRWDPVEYGGVEVLYVPSDTIWLPDVVLYNNADGNYQVTIMTKAKLTYNGTVE 140

  Fly   159 WTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDL----KHISQKNDKDNK-------- 211
            |.||||:||.|:|||.:||||:|.|.||||||||.|.::||    ||:.::.::|.:
Worm   141 WAPPAIYKSMCQIDVEFFPFDRQQCEMKFGSWTYGGLEVDLQHRDKHLEKEIEEDVEGVDGPTKE 205

  Fly   212 ----VEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPC 272
                |:.||||.:||||||||||.||.:||.|.||||..|:.||.:.|.|||||||||||||.|.
Worm   206 IVWVVDRGIDLSDYYPSVEWDILNVPGKRHSKRYPCCESPFIDITYEIHLRRKTLFYTVNLIFPS 270

  Fly   273 VGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGL 337
            ||||:|:.||||||:|.||||:||||||:|.|:||||:.||||||||.:||:||||||||:||.|
Worm   271 VGISFLTALVFYLPSDGGEKISLCISILISLTVFFLLLVEIIPSTSLVIPLIGKYLLFTMVLVTL 335

  Fly   338 SVVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKF 402
            |||:|::.||:|||.|:||.|..|::..|:..|||.|||..|
Worm   336 SVVVTVVTLNVHYRSPTTHTMPKWMKRLFVDFLPKYLLMTRP----------------------- 377

  Fly   403 GQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLP 467
                    |.....|.|:  |:...|.........||             ||.....||     |
Worm   378 --------QPPGHHSKPN--RKFDSRASTFSIGVNHV-------------LGQNSELLS-----P 414

  Fly   468 SVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLF 532
            .:.|..::| |....|...|  :..|:.:|.:|..|::.:::.....:||.::::||||:||..|
Worm   415 GLNSNREES-SFTLPRDNSP--VRSAVESVAYIADHLKNEEDDKQVIEDWKYISVVMDRIFLITF 476

  Fly   533 MIASLVGTFVILGEAPSLYDDTKAI 557
            ..|...||.||:..|||:||:|.|:
Worm   477 TFACAFGTVVIIARAPSIYDNTPAL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	136/234 (58%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	248/512 (48%)
unc-63	NP_491533.2	LIC	6..487	CDD:273305	255/529 (48%)
		Neur_chan_LBD	29..259	CDD:280998	132/229 (58%)
		Neur_chan_memb	266..487	CDD:280999	107/274 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	297	1.000	Domainoid score	I784
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		otm14483
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.890