DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRalpha2 and unc-38

DIOPT Version :9

Sequence 1:NP_524482.1 Gene:nAChRalpha2 / 42919 FlyBaseID:FBgn0000039 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_491472.1 Gene:unc-38 / 172105 WormBaseID:WBGene00006774 Length:511 Species:Caenorhabditis elegans


Alignment Length:551 Identity:257/551 - (46%)
Similarity:343/551 - (62%) Gaps:76/551 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 LLLVLLLLC----ETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKD 88
            |.|:|||.|    :..:.|.|||||||||:.||||..||.::....:.:||.|||||:||::..|
 Worm     6 LFLLLLLFCISFIKLTEGNEDAKRLYDDLMVNYNRHRRPSTSPNKPLTIKLKLRLSQIIDVHEID 70

  Fly    89 QILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHY 153
            ||:|.:|||:..|.|.|..|||..||||..||||.|.||:||||||||||..|.:|..|||.|||
 Worm    71 QIMTCSVWLKQTWIDRKLSWDPVNYGGVNVLYVPYEMIWVPDIVLYNNADSNYNITISTKATLHY 135

  Fly   154 TGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDL----------KHISQKNDK 208
            ||:|.|.|||||||.|:||||:||||:|.|.:||||||:..:.:.:          :.|.:|...
 Worm   136 TGEVTWEPPAIFKSMCQIDVRWFPFDEQQCHLKFGSWTFSENLLSVELNEPSLRYEEEIDEKGII 200

  Fly   209 DN--KVEIGIDLREYYPSVEWDILGVPAERHEKYYP-CCAE-PYPDIFFNITLRRKTLFYTVNLI 269
            ||  ..|.||||.:|||||||||:...|:|..|.|| ||.: .|.|:.:.:.||||.|||||||:
 Worm   201 DNVTVAEDGIDLSDYYPSVEWDIMSRVAKRRAKNYPSCCPQSAYIDVTYYLQLRRKPLFYTVNLV 265

  Fly   270 IPCVGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLL 334
            .||||||:|::||||||:|||||:.||||||::.|:||||::||||:||:.|||:||||||||::
 Worm   266 FPCVGISFLTILVFYLPSDSGEKVTLCISILVALTIFFLLLTEIIPATSITLPLIGKYLLFTMVM 330

  Fly   335 VGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSK 399
            |.||||:|:|.||:|:|.|:||.|..|::..|:|.|||||.||.|.|          :|..||. 
 Worm   331 VTLSVVVTVISLNLHFRTPTTHLMPNWVKKVFLKWLPKLLFMRRPID----------DYEEKFD- 384

  Fly   400 TKFGQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYN 464
                                |..:...|::..    .:|....:|        :|..:...:   
 Worm   385 --------------------DKKKPKDGKIAL----SVHAHRVSN--------VGNNIRNAT--- 414

  Fly   465 GLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFL 529
                    :||::.    :..|...:.||..|:.||...::::|..:..|:||.:||||:|||||
 Worm   415 --------IDDTIQ----KMYYSPPVVKAFENICFIAELLKKKDRDDKIDEDWKYVAMVLDRLFL 467

  Fly   530 WLFMIASLVGTFVILGEAPSLYDDTKAIDVQ 560
            .:|.||..|||.:||..||:|||..:.||:|
 Worm   468 LIFSIACFVGTVIILLRAPTLYDTRQPIDLQ 498

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha2NP_524482.1 LGIC_ECD_nAChR_proto_alpha-like 44..263 CDD:349832 125/232 (54%)
LIC 47..544 CDD:273305 237/510 (46%)
unc-38NP_491472.1 Neur_chan_LBD 27..257 CDD:280998 123/229 (54%)
LIC 29..483 CDD:273305 238/511 (47%)
Neur_chan_memb 264..481 CDD:280999 109/274 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 524 1.000 Inparanoid score I677
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45250
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 1 1.000 - - FOG0000583
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X294
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
109.940

Return to query results.
Submit another query.