DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and Chrnb3

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_598281.1	Gene:	Chrnb3 / 171131	RGDID:	621544	Length:	464	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	204/517 - (39%)
Similarity:	301/517 - (58%)	Gaps:	94/517 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 TVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQ 102
            :|..:.||  |...|...|.:.:|||.|::|.:.|..||::|||:|::.|:|::||||||:.||.
  Rat    30 SVAEHEDA--LLRHLFQGYQKWVRPVLNSSDIIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWT 92

  Fly   103 DHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGKVVWTPPAIFKS 167
            |.|.:|:|.||||:..:.||||.:|||||||:.||||.:..:.|||||:..:|.|.|||||.:||
  Rat    93 DQKLRWNPEEYGGINSIKVPSESLWLPDIVLFENADGRFEGSLMTKAIVKSSGTVSWTPPASYKS 157

  Fly   168 SCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDIL-- 230
            ||.:||.:||||:|.|.||||||||||..:||..|::          .:|.::::.:.||:||
  Rat   158 SCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINE----------NVDRKDFFDNGEWEILNA 212

  Fly   231 -GVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIA 294
             |:...|.|.:|     .||.:.::..|||..||||:.|||||:|:|:|:|||||||:|.|||::
  Rat   213 KGMKGNRREGFY-----SYPFVTYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLS 272

  Fly   295 LCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPST-HKM 358
            |..|:|:|.|:|.|:|.|||||:|..:||:|:||||.|:.|.||:::|:.::|:|:|..|| |.|
  Rat   273 LSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPM 337

  Fly   359 RPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQMNSGGSSPDSLR 423
            .||::..|::|||:.|.|:.|                           ||......|..|..::|
  Rat   338 APWVKRLFLQRLPRWLCMKDP---------------------------MDRFSFPDGKESDTAVR 375

  Fly   424 RMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSLSDVAARKKYPF 488
                    |..:|....|..:          .|...|..:
  Rat   376 --------GKVSGKRKQTPAS----------DGERVLVAF------------------------- 397

  Fly   489 ELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGTFVILGEAPSL 550
             ||||..::.:|..|::::...:...|||.|||.|:||:|||||:|||::|:.:|.  .|:|
  Rat   398 -LEKASESIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIASVLGSILIF--IPAL 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	101/221 (46%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	198/500 (40%)
Chrnb3	NP_598281.1	LIC	29..455	CDD:273305	202/514 (39%)
		Neur_chan_LBD	35..239	CDD:280998	101/220 (46%)
		Neur_chan_memb	246..452	CDD:280999	95/276 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I1995
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm12327
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830