DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and Chrna2

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_596911.1	Gene:	Chrna2 / 170945	RGDID:	621533	Length:	511	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	239/560 - (42%)
Similarity:	325/560 - (58%)	Gaps:	99/560 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LAH----IWRHCKPLCLLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGL 76
            |:|    .|.|....|||||..:|.:.........||:..|...|||..|||.|.:|.|:|:.||
  Rat     3 LSHSALQFWTHLYLWCLLLVPAVLTQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVRFGL 67

  Fly    77 RLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEY 141
            .::||||::.|:|::||||||:.||.|:|.:|||:|:|.||.|.||||.||:||||||||||||:
  Rat    68 SIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNVTSLRVPSEMIWIPDIVLYNNADGEF 132

  Fly   142 VVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKN 206
            .||.||||.|.:||.|.|.||||:||||.|||.:||||||.|.|||||||||..:|||:
  Rat   133 AVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLE------ 191

  Fly   207 DKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIP 271
                ::|..:||::|:.|.||.|:......:.|.|.||||.|||:.:...:||..||||:|||||
  Rat   192 ----QMERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIP 252

  Fly   272 CVGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVG 336
            |:.||.|:|||||||::.||||.||||:|||.|:|.|||:||||||||.:||:|:||||||:.|.
  Rat   253 CLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVT 317

  Fly   337 LSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTK 401
            ||:|||:.:||:|:|.||||.|..|:|...:.|:|:.|:|..|
  Rat   318 LSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRP---------------------- 360

  Fly   402 FGQALMDEMQMNSGGSSPD-----SLRRMQGRVGAGG-----------------CNGMHVTTATN 444
                 :..|:::   .|||     |...::..:.||.                 |.|:.
  Rat   361 -----LPPMELH---GSPDLKLSPSYHWLETNMDAGEREETEEEEEEEDENICVCAGLP------ 411

  Fly   445 RFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSLSDVAARKKYPF---------ELEKAIHNVMFI 500
                     ...:..|.|:.||         .|..:....|.|.         :::||:..|.:|
  Rat   412 ---------DSSMGVLYGHGGL---------HLRAMEPETKTPSQASEILLSPQIQKALEGVHYI 458

  Fly   501 QHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGT 540
            ...::.:|..::..:||.:||||:||:|||||:|...:||
  Rat   459 ADRLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGT 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	117/218 (54%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	229/525 (44%)
Chrna2	NP_596911.1	LIC	35..504	CDD:273305	229/528 (43%)
Chrna2	NP_596911.1	LGIC_ECD_nAChR_A2	36..242	CDD:349816	117/215 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I1995
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20193
Inparanoid	1	1.050	477	1.000	Inparanoid score	I1422
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm12327
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.880