DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha2 and HTR3C

DIOPT Version :10

Sequence 1:NP_524482.1 Gene:nAChRalpha2 / 42919 FlyBaseID:FBgn0000039 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_570126.2 Gene:HTR3C / 170572 HGNCID:24003 Length:447 Species:Homo sapiens


Alignment Length:408 Identity:108/408 - (26%)
Similarity:183/408 - (44%) Gaps:62/408 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 W--RHCKPLCLLLVLLLLCETVQANPDA------------------KRLYDDLLSNYNRLIRPVS 64
            |  |....|||.:.|||     |...||                  :.::|      .:..||.:
Human     5 WPARQSALLCLTVSLLL-----QGRGDAFTINCSGFDQHGVDPAVFQAVFD------RKAFRPFT 58

  Fly    65 NNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLP 129
            |.:....|.:...||.::.::.:.|:||:.:|::..|.:....|:|.|..|:.:|.|.:|::|||
Human    59 NYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLP 123

  Fly   130 DIVLYNNADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDG 194
            ||.:..:.|.:...:.:| |.:...|::.:..|....|.|.:|:.|||||||.|...|.|:.|..
Human   124 DIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTV 187

  Fly   195 DQIDL---KHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCA---EPYPDIFF 253
            |.:.|   |.:.:..|...||        .....||::||:     .|..|..:   ..|..|.|
Human   188 DSMLLGMDKEVWEITDTSRKV--------IQTQGEWELLGI-----NKATPKMSMGNNLYDQIMF 239

  Fly   254 NITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTS 318
            .:.:||:...|.:||::|...:..:..|.|||||:|..:....|::||...:|.|::::::|:: 
Human   240 YVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPAS- 303

  Fly   319 LALPLLGKYLLFTMLLVGLSVVITIIILN-IHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDL 382
             ..||:..|....:.|:.:|::.|:.|.. :|........|..|:.|        |||.......
Human   304 -GTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHS--------LLLHCTSPGR 359

  Fly   383 LRDLAANKINYGLKFSKT 400
            ....|..|.|.||..:.|
Human   360 CCPTAPQKGNKGLGLTLT 377

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha2NP_524482.1 LGIC_ECD_nAChR_proto_alpha-like 44..263 CDD:349832 62/242 (26%)
LIC 47..544 CDD:455710 97/361 (27%)
Cys-loop 169..183 CDD:349832 9/13 (69%)
HTR3CNP_570126.2 LGIC_ECD_5-HT3C_E 31..246 CDD:349814 59/234 (25%)
Cys-loop 162..176 CDD:349814 9/13 (69%)
LGIC_TM_5-HT3 248..446 CDD:349865 37/140 (26%)
TM1 helix 248..272 CDD:349865 7/23 (30%)
TM2 helix 280..301 CDD:349865 5/20 (25%)
TM3 helix 310..332 CDD:349865 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..405
HA-stretch, determines single-channel conductance in 5-HT3 receptors. /evidence=ECO:0000250|UniProtKB:P46098 401..423
TM4 helix 421..443 CDD:349865
Blue background indicates that the domain is not in the aligned region.

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