DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha2 and HTR3C

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_570126.2	Gene:	HTR3C / 170572	HGNCID:	24003	Length:	447	Species:	Homo sapiens

Alignment Length:	408	Identity:	108/408 - (26%)
Similarity:	183/408 - (44%)	Gaps:	62/408 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 W--RHCKPLCLLLVLLLLCETVQANPDA------------------KRLYDDLLSNYNRLIRPVS 64
            |  |....|||.:.|||     |...||                  :.::|      .:..||.:
Human     5 WPARQSALLCLTVSLLL-----QGRGDAFTINCSGFDQHGVDPAVFQAVFD------RKAFRPFT 58

  Fly    65 NNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLP 129
            |.:....|.:...||.::.::.:.|:||:.:|::..|.:....|:|.|..|:.:|.|.:|::|||
Human    59 NYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLP 123

  Fly   130 DIVLYNNADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDG 194
            ||.:..:.|.:...:.:| |.:...|::.:..|....|.|.:|:.|||||||.|...|.|:.|..
Human   124 DIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTV 187

  Fly   195 DQIDL---KHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCA---EPYPDIFF 253
            |.:.|   |.:.:..|...||        .....||::||:     .|..|..:   ..|..|.|
Human   188 DSMLLGMDKEVWEITDTSRKV--------IQTQGEWELLGI-----NKATPKMSMGNNLYDQIMF 239

  Fly   254 NITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTS 318
            .:.:||:...|.:||::|...:..:..|.|||||:|..:....|::||...:|.|::::::|::
Human   240 YVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPAS- 303

  Fly   319 LALPLLGKYLLFTMLLVGLSVVITIIILN-IHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDL 382
             ..||:..|....:.|:.:|::.|:.|.. :|........|..|:.|        |||.......
Human   304 -GTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHS--------LLLHCTSPGR 359

  Fly   383 LRDLAANKINYGLKFSKT 400
            ....|..|.|.||..:.|
Human   360 CCPTAPQKGNKGLGLTLT 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	62/242 (26%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	97/361 (27%)
HTR3C	NP_570126.2	Neur_chan_LBD	43..445	CDD:332142	97/365 (27%)
HTR3C	NP_570126.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..405
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810