Protein Alignment nAChRalpha2 and Htr3a

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_038589.2
• Gene: Htr3a / 15561
• MGIID: 96282
• Length: 489
• Species: Mus musculus
• Alignment Length: 558
• Identity: 135/558 - (24%)
• Similarity: 252/558 - (45%)
• Gaps: 113/558 - (20%)

  Fly    21 RHCKPLCLLLVLLLLC---------------ETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTV 70
            |.|.|..||.:.|.:.               :|.|  |...||.|.||:||.:.:|||.:.....
Mouse     2 RLCIPQVLLALFLSMLTAPGEGSRRRATQARDTTQ--PALLRLSDHLLANYKKGVRPVRDWRKPT 64

  Fly    71 LVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYN 135
            .|.:.:.:..:::::.|:|:|||.:|....|.|...:|.|.::..||:|.:|::.||:|||::
Mouse    65 TVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILI-- 127

  Fly   136 NADGEYVVTTMTKAI----LHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQ 196
               .|:|....:..|    :|:.|:|....|....::|.:|:..||||.|.|.:.|.||.:....
Mouse   128 ---NEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQD 189

  Fly   197 IDL----KHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITL 257
            |::    .....::||...:..|          ||::|.| ..:.:::....:..|.::.|.:.:
Mouse   190 INITLWRSPEEVRSDKSIFINQG----------EWELLEV-FPQFKEFSIDISNSYAEMKFYVII 243

  Fly   258 RRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALP 322
            ||:.|||.|:|::|.:.:..:.::.|.||.||||:::..|::||..::|.:::|:.:|:|::..|
Mouse   244 RRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTP 308

  Fly   323 LLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLM-------RVPK 380
            |:|.|.:..|.|:.:|:..||.|:.:.:::.....:..|:|...:.|:..:|.:       |.|
Mouse   309 LIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILCLGEQPMAHRPP- 372

  Fly   381 DLLRDLAANKINYGLKFSKTKFGQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNR 445
               ....|||.:                                        .|:|
Mouse   373 ---ATFQANKTD----------------------------------------DCSG--------- 385

  Fly   446 FSGLVGALGGGLSTLSGYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVM----FIQHHMQR 506
             |.|:.|:|...|.:.|...|.....|....|..       |.|...|:..::    .|:|.:::
Mouse   386 -SDLLPAMGNHCSHVGGPQDLEKTPRGRGSPLPP-------PREASLAVRGLLQELSSIRHFLEK 442

  Fly   507 QDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGTFVIL 544
            :||.....:||..|..|:|||...::::|.|..:..::
Mouse   443 RDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLV 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	60/226 (27%)
		LIC	47..544	CDD:273305	126/515 (24%)
Htr3a	NP_038589.2	LIC	5..483	CDD:273305	133/555 (24%)
		HA-stretch	425..461		9/35 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810