Protein Alignment nAChRalpha2 and CHRNG

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_005190.4
• Gene: CHRNG / 1146
• HGNCID: 1967
• Length: 517
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 186/567 - (32%)
• Similarity: 282/567 - (49%)
• Gaps: 111/567 - (19%)

  Fly    25 PLCLLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQ 89
            || |||:||.:|...|.....:||..||:.||:..:||...::|.|.|.|.|.|:.||.||.:::
Human     7 PL-LLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREE 70

  Fly    90 ILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYT 154
            .||||||:|.:|.|::.:|||.:|.|:..|.|||..:|.|||||.||.||.:.|......::...
Human    71 ALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPD 135

  Fly   155 GKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVE-IGIDL 218
            |.:.|.|||||:|:|.|.|.|||||.|.|.:.|.|.||..::|||: :||::.:  .:| |.||.
Human   136 GCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQ-LSQEDGQ--TIEWIFIDP 197

  Fly   219 REYYPSVEWDILGVPAER------------HEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIP 271
            ..:..:.||.|...||:.            |:|           :.|.:.::||.|||.:|:|.|
Human   198 EAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQK-----------VVFYLLIQRKPLFYVINIIAP 251

  Fly   272 CVGISYLSVLVFYLPADS-GEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLV 335
            ||.||.:::|:.:|||.: |:|..:.|::||:||:|..|:::.:|.||.|:||:.|||.|.:::.
Human   252 CVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVT 316

  Fly   336 GLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKT 400
            .|.||..:::||:..|.|.||.|...:|..|::.||:||.|.|     |.||
Human   317 ILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHV-----RPLA------------- 363

  Fly   401 KFGQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATN---------------RFSGLV 450
                              |.:::..|.|: ..|.:|..:||...               :..|||
Human   364 ------------------PAAVQDTQSRL-QNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLV 409

  Fly   451 GALGGGLSTLSGYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIH------NVMFIQHHMQRQDE 509
            .|            .|..:..|.:..||......|   :...||.      |::....|  :|..
Human   410 AA------------ALEKLEKGPELGLSQFCGSLK---QAAPAIQACVEACNLIACARH--QQSH 457

  Fly   510 FNAEDQDWGFVAMVMDRL----FLWLFMIASLVGTFVI--LGEAPSL 550
            |:..:::|..|..|:||:    .|.|| |....|.|::  ....|:|
Human   458 FDNGNEEWFLVGRVLDRVCFLAMLSLF-ICGTAGIFLMAHYNRVPAL 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	88/231 (38%)
		LIC	47..544	CDD:273305	175/537 (33%)
CHRNG	NP_005190.4	LGIC_ECD_nAChR_G	49..241	CDD:349830	79/205 (39%)
		Neur_chan_memb	248..492	CDD:397193	82/298 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910