Protein Alignment nAChRalpha2 and CHRNE

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_000071.1
• Gene: CHRNE / 1145
• HGNCID: 1966
• Length: 493
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 177/545 - (32%)
• Similarity: 265/545 - (48%)
• Gaps: 102/545 - (18%)

  Fly    25 PLCLLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQ 89
            ||.:||:|.||...|..|.:. |||..|.:||:...|||....|||.:.|.:.|:.||.||.|::
Human     5 PLGVLLLLGLLGRGVGKNEEL-RLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEE 68

  Fly    90 ILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYT 154
            .|||:||:..:|||::..:...::||:..|.||||.:|||:|||.||.||::.|......:::..
Human    69 TLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEG 133

  Fly   155 GKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKV--EIGID 217
            |.|.|.||||::|.|.::|.|||||.|.|.:.|.|.||:.::::.....   |.|.|.  :|.||
Human   134 GSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAV---DNDGKTINKIDID 195

  Fly   218 LREYYPSVEWDILGVPA--ERHEKYYPCCAEPYP---DIFFNITLRRKTLFYTVNLIIPCVGISY 277
            ...|..:.||.|...|.  .||..    .|...|   |:.:::.:|||.|||.:|:|:|||.||.
Human   196 TEAYTENGEWAIDFCPGVIRRHHG----GATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISG 256

  Fly   278 LSVLVFYLPADS-GEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVI 341
            |.:|.::|||.: |:|..:.|::||:||:|..||::.||.|||::||||::|:|.|::..|.|:.
Human   257 LVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMN 321

  Fly   342 TIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKD----------------LLR--DLAA 388
            .:|:||:..|.|:||.|.|.:|...::.||:||....|.:                |||  :|..
Human   322 CVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRASSVGLLLRAEELIL 386

  Fly   389 NKINYGLKFSKTKFGQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGAL 453
            .|....|.|.    ||                  |..||...|..|
Human   387 KKPRSELVFE----GQ------------------RHRQGTWTAAFC------------------- 410

  Fly   454 GGGLSTLSGYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWG 518
                                 .||...|.      |:...:..|.|:....:.|:....|..||.
Human   411 ---------------------QSLGAAAP------EVRCCVDAVNFVAESTRDQEATGEEVSDWV 448

  Fly   519 FVAMVMDRLFLWLFMIASLVGTFVI 543
            .:...:|.:..|..::...||:.:|
Human   449 RMGNALDNICFWAALVLFSVGSSLI 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	85/225 (38%)
		LIC	47..544	CDD:273305	168/523 (32%)
CHRNE	NP_000071.1	LIC	21..475	CDD:273305	169/529 (32%)
		Neur_chan_LBD	24..240	CDD:280998	84/223 (38%)
		Neur_chan_memb	247..474	CDD:280999	79/295 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910