Protein Alignment nAChRalpha2 and Chrna6

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_067344.2
• Gene: Chrna6 / 11440
• MGIID: 106213
• Length: 494
• Species: Mus musculus
• Alignment Length: 529
• Identity: 213/529 - (40%)
• Similarity: 312/529 - (58%)
• Gaps: 75/529 - (14%)

  Fly    23 CKPLCLLLVLL---LLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDL 84
            |..||..|.|.   ..||:      .::|:..|.::|||.||||.|.:|.|.|...|.::||.::
Mouse    15 CLWLCGFLALFKGSTGCES------EEQLFHRLFAHYNRFIRPVENVSDPVTVHFELAITQLANV 73

  Fly    85 NLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKA 149
            :..:||:.||:||.|.|:|::.:|||:||.|:..|.||:::||.|||||||||.|::.|...|||
Mouse    74 DEVNQIMETNLWLRHIWKDYRLRWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKA 138

  Fly   150 ILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEI 214
            :|.|.|.:.|||||||||||.:|:.:||||.|.|.:||||||||..:|||..|..|
Mouse   139 LLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSK--------- 194

  Fly   215 GIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLS 279
             :|:.:::.:.||:|:.....:|:..|.||.|.|.||.::..:||..:|||:||||||:.||:|:
Mouse   195 -VDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLT 258

  Fly   280 VLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITII 344
            |||||||:|.|||:.||||:|||.|:|.|:|:|.||||||.:||:|:||||||:.|.||:|:|:.
Mouse   259 VLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVF 323

  Fly   345 ILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANK--INYGLKFSKTKF---GQ 404
            :||||||.|:||.|..|:::.|::..|.:|:||.|.|..::....|  .::..:.:|.||   |:
Mouse   324 VLNIHYRTPATHTMPKWVKTIFLQAFPSILMMRKPLDKTKEAGGVKDPKSHTKRPAKVKFTHRGE 388

  Fly   405 A-LMDEMQ--MNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGL 466
            : |:.|..  ..|...:|...|..|
Mouse   389 SKLLKECHHCQKSSDIAPGKRRSSQ---------------------------------------- 413

  Fly   467 PSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWL 531
                    .....||...::..::|..|.:|.||..:|:..:|.|..:.||.::|||:||:|||:
Mouse   414 --------QPARWVAENSEHSSDVEDVIESVQFIAENMKSHNETNEVEDDWKYMAMVVDRVFLWV 470

  Fly   532 FMIASLVGT 540
            |:|..:.||
Mouse   471 FIIVCVFGT 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	98/218 (45%)
		LIC	47..544	CDD:273305	206/502 (41%)
Chrna6	NP_067344.2	LIC	15..484	CDD:273305	213/529 (40%)
		Neur_chan_LBD	34..240	CDD:280998	98/215 (46%)
		Neur_chan_memb	247..483	CDD:280999	104/281 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..423		6/71 (8%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2060
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	476	1.000	Inparanoid score	I1470
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm8871
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980