DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and CHRND

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_000742.1	Gene:	CHRND / 1144	HGNCID:	1965	Length:	517	Species:	Homo sapiens

Alignment Length:	526	Identity:	197/526 - (37%)
Similarity:	293/526 - (55%)	Gaps:	64/526 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LLVLLLLCETVQANPDAKRLYDDLL--SNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQIL 91
            ||..|.:|.:...| :.:||...|.  ..||:.:|||::..::|.|.|.|.||.||.|...::.|
Human    10 LLAALAVCGSWGLN-EEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETL 73

  Fly    92 TTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGK 156
            |||||:||.|.|::.||:..|:|.::.|.:|.:.:|||:|||.||.||.:.::.....::::.|.
Human    74 TTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGF 138

  Fly   157 VVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKND-KDNK---VE-IGI 216
            |.|.|||||:|||.|.|.|||||.|.|.:||.|..|...:|.|   |.|.| |:|:   || |.|
Human   139 VYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITL---SLKQDAKENRTYPVEWIII 200

  Fly   217 DLREYYPSVEWDILGVPAERH-EKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSV 280
            |...:..:.||:|:..||..: :...|..:....||.|.:.:|||.|||.:|:::|||.||::..
Human   201 DPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVN 265

  Fly   281 LVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIII 345
            ||||||||||||.::.||:||:|::|.||||:.:|:||:|:||:||:|||.|:||.:.|||.:|:
Human   266 LVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIV 330

  Fly   346 LNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEM 410
            ||||:|.||||.:...::..|::.||:||.|..|.:
Human   331 LNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAE----------------------------- 366

  Fly   411 QMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRF-----SGLVGALGGGLSTLSGYNGLPSVL 470
                .|.||.:|.|....:|       :::.|...|     |.|:      ....|..:||...|
Human   367 ----DGPSPGALVRRSSSLG-------YISKAEEYFLLKSRSDLM------FEKQSERHGLARRL 414

  Fly   471 -SGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMI 534
             :......|...|:::...||:.|:....||.:||:.|:.:|.|...|..||..:|||.|::...
Human   415 TTARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTP 479

  Fly   535 ASLVGT 540
            ..:|||
Human   480 VMVVGT 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	91/226 (40%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	192/508 (38%)
CHRND	NP_000742.1	Neur_chan_LBD	25..246	CDD:308532	90/223 (40%)
CHRND	NP_000742.1	Neur_chan_memb	253..489	CDD:308533	97/279 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810