DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRalpha2 and Chrna1

DIOPT Version :9

Sequence 1:NP_524482.1 Gene:nAChRalpha2 / 42919 FlyBaseID:FBgn0000039 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_031415.2 Gene:Chrna1 / 11435 MGIID:87885 Length:457 Species:Mus musculus


Alignment Length:521 Identity:203/521 - (38%)
Similarity:291/521 - (55%) Gaps:81/521 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 LCLLLVLLLLCET--VQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKD 88
            |..:|:||.||..  |..:....||...|..:|:.::|||.::.:.|.|.:||:|.|||:::..:
Mouse     3 LSTVLLLLGLCSAGLVLGSEHETRLVAKLFEDYSSVVRPVEDHREIVQVTVGLQLIQLINVDEVN 67

  Fly    89 QILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHY 153
            ||:||||.|:.:|.|:..||:|.:||||.::::|||.||.||:||||||||::.:...||.:|.|
Mouse    68 QIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDFAIVKFTKVLLDY 132

  Fly   154 TGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDL 218
            ||.:.|||||||||.|||.|.:||||:|.|.||.|:|||||..:.:...|.:.|..|.:|.|   
Mouse   133 TGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESG--- 194

  Fly   219 REYYPSVEWDILGVPAERHEKYYPCC-AEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLV 282
                   ||.|......:|..:|.|| ..||.||.::..::|..|::.||:||||:..|:|:.||
Mouse   195 -------EWVIKEARGWKHWVFYSCCPTTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTSLV 252

  Fly   283 FYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILN 347
            ||||.|||||:.|.||:|||.|:|.|:|.|:|||||.|:||:|||:||||:.|..|::||:|::|
Mouse   253 FYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVIN 317

  Fly   348 IHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQM 412
            .|:|.||||.|..|:|..||..:|.::.....|...||          |..|..|.:.:      
Mouse   318 THHRSPSTHIMPEWVRKVFIDTIPNIMFFSTMKRPSRD----------KQEKRIFTEDI------ 366

  Fly   413 NSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSL 477
                                                       .:|.:||..|.|.:  |....|
Mouse   367 -------------------------------------------DISDISGKPGPPPM--GFHSPL 386

  Fly   478 SDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGTFV 542
            .      |:| |::.||..|.:|...|:...|.|...::|.:||||||.:.|.:||:..|:||..
Mouse   387 I------KHP-EVKSAIEGVKYIAETMKSDQESNNAAEEWKYVAMVMDHILLGVFMLVCLIGTLA 444

  Fly   543 I 543
            :
Mouse   445 V 445

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha2NP_524482.1 LGIC_ECD_nAChR_proto_alpha-like 44..263 CDD:349832 96/219 (44%)
LIC 47..544 CDD:273305 196/498 (39%)
Chrna1NP_031415.2 Neur_chan_LBD 24..231 CDD:308532 96/216 (44%)
Neur_chan_memb 238..446 CDD:308533 97/276 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.920

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