Protein Alignment nAChRalpha2 and CHRNB4

DIOPT Version :10

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_000741.1
• Gene: CHRNB4 / 1143
• HGNCID: 1964
• Length: 498
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 210/530 - (39%)
• Similarity: 306/530 - (57%)
• Gaps: 74/530 - (13%)

  Fly    25 PLCLLLVLLLLC---ETVQANPDAKRLYDDLL--SNYNRLIRPVSNNTDTVLVKLGLRLSQLIDL 84
            |..:|..|:.||   ....||.:.| |.||||  :.||.||||.::::..:.:||.|.|:|||.:
Human     5 PSLVLFFLVALCGRGNCRVANAEEK-LMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISV 68

  Fly    85 NLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKA 149
            |.::||:||||||:.||.|::..|:.|.|.||..|.:|::.||||||||||||||.|.|:..|..
Human    69 NEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNL 133

  Fly   150 ILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEI 214
            |:...|.|:|.||||:||:|:|:|:|||||||.|.:||.|||||..:||:..::.....|
Human   134 IVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMD----- 193

  Fly   215 GIDLREYYPSVEWDILGVPAERHEKYYPCCAEP----YPDIFFNITLRRKTLFYTVNLIIPCVGI 275
                 ::.||.||||:.:|..|       ...|    |.|:.::..::||.||||:|||||||..
Human   194 -----DFTPSGEWDIVALPGRR-------TVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLT 246

  Fly   276 SYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVV 340
            :.|::||||||:|.|||:.||||:||:.|.|.||||:|:|.|||.:||:||||:|||:||..|:|
Human   247 TLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIV 311

  Fly   341 ITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKF--- 402
            .::.:||:|:|.||||.|.||::..|:.:||..|.|:.|              |...|..:.
Human   312 TSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRP--------------GPDSSPARAFPP 362

  Fly   403 GQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLP 467
            .::.:.:.:..:..:||.:...          |.|:.....:            .::.|.....|
Human   363 SKSCVTKPEATATSTSPSNFYG----------NSMYFVNPAS------------AASKSPAGSTP 405

  Fly   468 SVLSGLDDSLSDVAARKKYPF--ELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLW 530
            ..:.      .|...|....|  ::::|:..|.||..||:..||..:..:||.:||||:||||||
Human   406 VAIP------RDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLW 464

  Fly   531 LFMIASLVGT 540
            :||...::||
Human   465 VFMFVCVLGT 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	99/224 (44%)
		LIC	47..544	CDD:455710	202/505 (40%)
		Cys-loop	169..183	CDD:349832	10/13 (77%)
CHRNB4	NP_000741.1	LIC	5..480	CDD:455710	210/530 (40%)
		LGIC_ECD	54..231	CDD:475126	85/193 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..377		0/19 (0%)