Protein Alignment nAChRalpha2 and CHRNB3

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_000740.1
• Gene: CHRNB3 / 1142
• HGNCID: 1963
• Length: 458
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 205/536 - (38%)
• Similarity: 305/536 - (56%)
• Gaps: 101/536 - (18%)

  Fly    29 LLVLLLL---------CETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDL 84
            :|||::|         ..::..|.||  |...|...|.:.:|||.::.||:.|..||::|||:|:
Human     6 MLVLIVLGIPSSATTGFNSIAENEDA--LLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDV 68

  Fly    85 NLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKA 149
            :.|:|::||||||:.||.|||.:|:|.:|||:..:.||||.:|||||||:.||||.:..:.|||.
Human    69 DEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKV 133

  Fly   150 ILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEI 214
            |:...|.|||||||.:||||.:||.:||||:|.|.||||||||||..:||..|::
Human   134 IVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINE---------- 188

  Fly   215 GIDLREYYPSVEWDIL---GVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGIS 276
            .:|.::::.:.||:||   |:...|.:..|     .||.|.::..|||..||||:.|||||:|:|
Human   189 NVDRKDFFDNGEWEILNAKGMKGNRRDGVY-----SYPFITYSFVLRRLPLFYTLFLIIPCLGLS 248

  Fly   277 YLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVI 341
            :|:|||||||:|.|||::|..|:|:|.|:|.|:|.|||||:|..:||:|:||||.|:.|.||:::
Human   249 FLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIV 313

  Fly   342 TIIILNIHYRKPST-HKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQA 405
            |:.::|:|:|..|| |.|.||::..|:::|||||.|:
Human   314 TVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMK---------------------------- 350

  Fly   406 LMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVL 470
              |.:...|.....:|...::|:|                                       :.
Human   351 --DHVDRYSSPEKEESQPVVKGKV---------------------------------------LE 374

  Fly   471 SGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIA 535
            ......|||  ..|.....||||..::.:|..|::::...:...|||.|||.|:||:|||||:|.
Human   375 KKKQKQLSD--GEKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIV 437

  Fly   536 SLVGTFVILGEAPSLY 551
            |:.|:.:|...|..::
Human   438 SVTGSVLIFTPALKMW 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	101/221 (46%)
		LIC	47..544	CDD:273305	196/500 (39%)
CHRNB3	NP_000740.1	Neur_chan_LBD	23..449	CDD:332142	200/513 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	251	1.000	Domainoid score	I2107
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830