Protein Alignment nAChRalpha2 and CHRNB2

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_000739.1
• Gene: CHRNB2 / 1141
• HGNCID: 1962
• Length: 502
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 225/540 - (41%)
• Similarity: 320/540 - (59%)
• Gaps: 88/540 - (16%)

  Fly    21 RHCKPLCLLL--VLLLLCETVQANPDAKRLYDDLL--SNYNRLIRPVSNNTDTVLVKLGLRLSQL 81
            |.|.|:.|||  .||.||..|......:||.:.||  |.||:||||.:|.::.|.|:|.:.|:||
Human     3 RRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQL 67

  Fly    82 IDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTM 146
            |.::.::||:||||||..||:|::..|.|.|:..:.::.:||:||||||:||||||||.|.|:..
Human    68 ISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFY 132

  Fly   147 TKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNK 211
            :.|::.|.|.:.|.||||:||:|:|:|::||||||.|.|||.|||||..:|||.         .|
Human   133 SNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLV---------LK 188

  Fly   212 VEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEP----YPDIFFNITLRRKTLFYTVNLIIPC 272
            .|:. .|.::.||.||||:.:|..|:|       .|    |.||.::..:|||.||||:||||||
Human   189 SEVA-SLDDFTPSGEWDIVALPGRRNE-------NPDDSTYVDITYDFIIRRKPLFYTINLIIPC 245

  Fly   273 VGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGL 337
            |.|:.|::||||||:|.|||:.||||:||:.|:|.||||:|:|.|||.:||:||||:|||:||..
Human   246 VLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTF 310

  Fly   338 SVVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKF 402
            |:|.::.:||:|:|.|:||.|.||::..|:::||.||.|:.|:   ...|..::..
Human   311 SIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPR---HHCARQRLRL--------- 363

  Fly   403 GQALMDEMQMNSGGSSPDSLRRMQGRVGAG--------GCNGMHVTTATNRFS--GLVGALGGGL 457
                               .||.:.|.|||        |.:.  .|...||.|  ||.||.|...
Human   364 -------------------RRRQREREGAGALFFREAPGADS--CTCFVNRASVQGLAGAFGAEP 407

  Fly   458 STLS--GYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFV 520
            :.::  |.:|.|....                  |.:|:..|.||..||:.:|:..:..:||.:|
Human   408 APVAGPGRSGEPCGCG------------------LREAVDGVRFIADHMRSEDDDQSVSEDWKYV 454

  Fly   521 AMVMDRLFLWLFMIASLVGT 540
            |||:||||||:|:...:.||
Human   455 AMVIDRLFLWIFVFVCVFGT 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	101/224 (45%)
		LIC	47..544	CDD:273305	214/512 (42%)
CHRNB2	NP_000739.1	LIC	29..479	CDD:273305	214/514 (42%)
		LGIC_ECD_nAChR_B2	31..234	CDD:349826	100/219 (46%)
		Cys-loop	155..169	CDD:349826	9/13 (69%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8639
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820