DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and CHRNA2

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_000733.2	Gene:	CHRNA2 / 1135	HGNCID:	1956	Length:	529	Species:	Homo sapiens

Alignment Length:	546	Identity:	240/546 - (43%)
Similarity:	324/546 - (59%)	Gaps:	72/546 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 APGCCTTRPRPIALL---AHIWRHCKPLCLLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPV 63
            |||...:.|.|.||.   :|                 .||      ..||:..|...|||..|||
Human    36 APGDPLSSPSPTALPQGGSH-----------------TET------EDRLFKHLFRGYNRWARPV 77

  Fly    64 SNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWL 128
            .|.:|.|:|:.||.::||||::.|:|::||||||:.||.|:|.:|:|:::|.:|.|.||||.||:
Human    78 PNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWI 142

  Fly   129 PDIVLYNNADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYD 193
            ||||||||||||:.||.||||.|..||.|.|.||||:||||.|||.:||||||.|.|||||||||
Human   143 PDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYD 207

  Fly   194 GDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLR 258
            ..:|||:.:.|.          :||::|:.|.||.|:......:.|.|.||||.|||:.:...:|
Human   208 KAKIDLEQMEQT----------VDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIR 262

  Fly   259 RKTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPL 323
            |..||||:||||||:.||.|:|||||||:|.||||.||||:|||.|:|.|||:||||||||.:||
Human   263 RLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPL 327

  Fly   324 LGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMR---VPKDLLRD 385
            :|:||||||:.|.||:|||:.:||:|:|.||||.|..|:|...:..:|:.|||.   .|.:|...
Human   328 IGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHP 392

  Fly   386 LAANKINYGLKFSKTKFGQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLV 450
            |.       ||.|.:      ...::.|......:.:...:.|....|    ||..:
Human   393 LR-------LKLSPS------YHWLESNVDAEEREVVVEEEDRWACAG----HVAPS-------- 432

  Fly   451 GALGGGLSTLSGYNGLPSVLSG-LDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAED 514
                  :.||..:..|.|..|| ..::|.........| .::||:..|.:|..|::.:|..::..
Human   433 ------VGTLCSHGHLHSGASGPKAEALLQEGELLLSP-HMQKALEGVHYIADHLRSEDADSSVK 490

  Fly   515 QDWGFVAMVMDRLFLWLFMIASLVGT 540
            :||.:||||:||:|||||:|...:||
Human   491 EDWKYVAMVIDRIFLWLFIIVCFLGT 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	114/218 (52%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	230/498 (46%)
CHRNA2	NP_000733.2	LIC	57..522	CDD:273305	232/508 (46%)
		Neur_chan_LBD	59..265	CDD:280998	114/215 (53%)
		Neur_chan_memb	272..520	CDD:280999	111/277 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	251	1.000	Domainoid score	I2107
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20193
Inparanoid	1	1.050	485	1.000	Inparanoid score	I1448
Isobase	1	0.950	-	0	Normalized mean entropy	S3454
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm8639
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.830