Protein Alignment nAChRalpha2 and CHRNA1

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: XP_016858745.1
• Gene: CHRNA1 / 1134
• HGNCID: 1955
• Length: 489
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 197/546 - (36%)
• Similarity: 287/546 - (52%)
• Gaps: 104/546 - (19%)

  Fly    24 KPLCLLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKD 88
            |.|.:|:...:....|..:....||...|..:|:.::|||.::...|.|.:||:|.|||:::..:
Human    10 KNLTVLVSSAVSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVN 74

  Fly    89 QILTTNVWLE-------------------------HEWQDHKFKWDPSEYGGVTELYVPSEHIWL 128
            ||:||||.|:                         .:|.|:..||:|.:||||.::::|||.||.
Human    75 QIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWR 139

  Fly   129 PDIVLYNNADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYD 193
            ||:||||||||::.:...||.:|.|||.:.|||||||||.|||.|.:||||:|.|.||.|:||||
Human   140 PDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYD 204

  Fly   194 GDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAE-PYPDIFFNITL 257
            |..:.:...|.:.|..|.:|.|          ||.|......:|...|.||.: ||.||.::..:
Human   205 GSVVAINPESDQPDLSNFMESG----------EWVIKESRGWKHSVTYSCCPDTPYLDITYHFVM 259

  Fly   258 RRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALP 322
            :|..|::.||:||||:..|:|:.||||||.|||||:.|.||:|||.|:|.|:|.|:|||||.|:|
Human   260 QRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVP 324

  Fly   323 LLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLA 387
            |:|||:||||:.|..|::||:|::|.|:|.||||.|..|:|..||..:|.::.....|...|:..
Human   325 LIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQ 389

  Fly   388 ANKINYGLKFSKTKFGQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGA 452
            ..||          |.:.:
Human   390 DKKI----------FTEDI---------------------------------------------- 398

  Fly   453 LGGGLSTLSGYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDW 517
               .:|.:||..|.|.:  |....|.      |:| |::.||..:.:|...|:...|.|....:|
Human   399 ---DISDISGKPGPPPM--GFHSPLI------KHP-EVKSAIEGIKYIAETMKSDQESNNAAAEW 451

  Fly   518 GFVAMVMDRLFLWLFMIASLVGTFVI 543
            .:||||||.:.|.:||:..::||..:
Human   452 KYVAMVMDHILLGVFMLVCIIGTLAV 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	96/244 (39%)
		LIC	47..544	CDD:273305	193/523 (37%)
CHRNA1	XP_016858745.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920