Protein Alignment nAChRalpha2 and Chrna2

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_659052.1
• Gene: Chrna2 / 110902
• MGIID: 87886
• Length: 512
• Species: Mus musculus
• Alignment Length: 527
• Identity: 234/527 - (44%)
• Similarity: 324/527 - (61%)
• Gaps: 44/527 - (8%)

  Fly    20 WRHCKPLCLLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDL 84
            |.|....||||:..:|.:.........||:..|...|||..|||.|.:|.|:|:.||.::||||:
Mouse    11 WIHLYLWCLLLMPAVLAQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDV 75

  Fly    85 NLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKA 149
            :.|:|::||||||:.||.|:|.:|||:|:|.:|.|.||||.||:||||||||||||:.||.||||
Mouse    76 DEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKA 140

  Fly   150 ILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEI 214
            .|.:||.|.|.||||:||||.|||.:||||||.|.|||||||||..:|||:          ::|.
Mouse   141 HLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLE----------QMER 195

  Fly   215 GIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLS 279
            .:||::|:.|.||.|:......:.|.|.||||.|||:.:...:||..||||:||||||:.||.|:
Mouse   196 TVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLT 260

  Fly   280 VLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITII 344
            |||||||::.||||.||||:|||.|:|.|||:||||||||.:||:|:||||||:.|.||:|||:.
Mouse   261 VLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVF 325

  Fly   345 ILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFS------KTKFG 403
            :||:|:|.||||.|..|:|...:.|:|:.|:|..|...: :|..:.   |||.|      :|...
Mouse   326 VLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRPLPPM-ELHGSP---GLKLSPTYHWLETNMD 386

  Fly   404 QALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPS 468
            ....:|.:........:::..         |.|:.               ...:..|.|:..|..
Mouse   387 AEEREETEEEEEEEEDENICM---------CAGLP---------------DSSMGVLYGHGSLHL 427

  Fly   469 VLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFM 533
            ...|.:......|:......:::||:..|.:|..|::.:|..::..:||.:||||:||:|||||:
Mouse   428 RAMGPEAKTPSQASEILLSPQIQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVVDRIFLWLFI 492

  Fly   534 IASLVGT 540
            |...:||
Mouse   493 IVCFLGT 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	116/218 (53%)
		LIC	47..544	CDD:273305	227/500 (45%)
Chrna2	NP_659052.1	LIC	15..505	CDD:273305	232/523 (44%)
		LGIC_ECD_nAChR_A2	36..242	CDD:349816	116/215 (54%)
		Cys-loop	160..174	CDD:349816	10/13 (77%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2060
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20193
Inparanoid	1	1.050	476	1.000	Inparanoid score	I1470
Isobase	1	0.950	-	0	Normalized mean entropy	S3454
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm8871
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.830