DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and Chrna5

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001360830.1	Gene:	Chrna5 / 110835	MGIID:	87889	Length:	467	Species:	Mus musculus

Alignment Length:	546	Identity:	195/546 - (35%)
Similarity:	297/546 - (54%)	Gaps:	121/546 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KPLCLLLVLLLLC-----------------ETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVL 71
            :.|.|||::.||.                 |...|......|:.||..:|.:.:|||.:.:|.:.
Mouse     9 RALRLLLMVQLLAGRWRPAGAARGARGGLPELSSAAKHEDSLFRDLFEDYEKWVRPVEHLSDKIK 73

  Fly    72 VKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNN 136
            :|.||.:|||:|::.|:|::||||||:.||.|.|.:|:|.:|||:..:.|||:.:|:|||||::|
Mouse    74 IKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKIIRVPSDSLWIPDIVLFDN 138

  Fly   137 ADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKH 201
            |||.:...: ||.::.|.|.|.||.||.:||||.|||.:||||.|.|.||||||||||.|:|:
Mouse   139 ADGRFEGAS-TKTVVRYNGTVTWTQPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDI-- 200

  Fly   202 ISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTV 266
            |.:..|        :|..:::.:.||:|:.....:..:...||.  ||.|.::..::|..||||:
Mouse   201 ILEDQD--------VDRTDFFDNGEWEIMSAMGSKGNRTDSCCW--YPCITYSFVIKRLPLFYTL 255

  Fly   267 NLIIPCVGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFT 331
            .|||||:|:|:|:|:|||||::.||||:||.|:|:|.|:|.|:|.|||||:|..:||:|:||:||
Mouse   256 FLIIPCIGLSFLTVVVFYLPSNEGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFT 320

  Fly   332 MLLVGLSVVITIIILNIHYRKPSTHK-MRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGL 395
            |:.|.||:::|:..:|||:|..|||. |.||:|..|:.:|||||.||...|          .|
Mouse   321 MIFVTLSIMVTVFAINIHHRSSSTHNAMAPWVRKIFLHKLPKLLCMRSHAD----------RY-- 373

  Fly   396 KFSKTKFGQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTL 460
                  |.|  .:|.:.:.|..|.::
Mouse   374 ------FTQ--REEAEKDGGPKSRNT--------------------------------------- 391

  Fly   461 SGYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMD 525
                                         ||.|:..:.:|..|:.::::.....:||.|:|.|:|
Mouse   392 -----------------------------LEAALDCIRYITRHVVKENDVREVVEDWKFIAQVLD 427

  Fly   526 RLFLWLFMIASLVGTFVILGEAPSLY 551
            |:|||.|::.|::||..:.  .|.:|
Mouse   428 RMFLWTFLLVSIIGTLGLF--VPVIY 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	91/218 (42%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	185/497 (37%)
Chrna5	NP_001360830.1	LGIC_ECD	45..251	CDD:355788	91/218 (42%)
Chrna5	NP_001360830.1	Neur_chan_memb	257..445	CDD:367256	90/275 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2060
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830