DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and Chrnb4

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_683746.1	Gene:	Chrnb4 / 108015	MGIID:	87892	Length:	495	Species:	Mus musculus

Alignment Length:	550	Identity:	220/550 - (40%)
Similarity:	314/550 - (57%)	Gaps:	91/550 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PLCLLLVLLLL----CETVQANPDAKRLYDDLL--SNYNRLIRPVSNNTDTVLVKLGLRLSQLID 83
            ||.|:.:..||    |....|.   ::|.||||  :.||.||||.::::..:.::|.|.|||||.
Mouse     5 PLLLVSLFALLQPGDCRLANAE---EKLMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLIS 66

  Fly    84 LNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTK 148
            :|.::||:||::||:.||.|::..|:.|.|.||..|.:|::.:|||||||||||||.|.|:..|.
Mouse    67 VNEREQIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNADGTYEVSVYTN 131

  Fly   149 AILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVE 213
            .|:...|.:.|.||||:||:|:|:|::||||||.|.:||.|||||..:||:...|.....|
Mouse   132 VIVRSNGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKSPTAIMD---- 192

  Fly   214 IGIDLREYYPSVEWDILGVPAERHEKYYPCCAEP----YPDIFFNITLRRKTLFYTVNLIIPCVG 274
                  ::.||.||||:.:|..|       ...|    |.|:.::..::||.||||:|||||||.
Mouse   193 ------DFTPSGEWDIVALPGRR-------TVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVL 244

  Fly   275 ISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSV 339
            |:.|::||||||:|.|||:.||||:||:.|.|.||||:|:|.|||.:||:||||||||:||..|:
Mouse   245 ITSLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLFTMVLVTFSI 309

  Fly   340 VITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKF-- 402
            |.|:.:||:|:|.||||.|..|::..|:.:||..|.|:.|              ||:.|..:.
Mouse   310 VTTVCVLNVHHRSPSTHTMASWVKECFLHKLPTFLFMKRP--------------GLEVSPARVPH 360

  Fly   403 -GQALMDEMQMNS----GGSSPDSLRRMQGRVGAGGCNGMHVTT---ATNRFSGLVGALGGGLST 459
             .|..:...:..|    |.|||.:|..          |.|:...   ||.:            |.
Mouse   361 SSQLHLTTAEATSTSALGPSSPSNLYG----------NSMYFVNPVPATPK------------SA 403

  Fly   460 LSGYN-GLPSVLSGLDDSLSDVAARKKYPF--ELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVA 521
            :|.:. |||          .|...|....|  :|::|:..|.||..|::..|...:..:||.|||
Mouse   404 VSSHTAGLP----------RDARLRSSGRFRQDLQEALEGVSFIAQHLESDDRDQSVIEDWKFVA 458

  Fly   522 MVMDRLFLWLFMIASLVGTFVILGEAPSLY 551
            ||:||||||:|:|..::||..:.  .|.|:
Mouse   459 MVVDRLFLWVFVIVCILGTMGLF--LPPLF 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	94/224 (42%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	211/515 (41%)
Chrnb4	NP_683746.1	LIC	21..483	CDD:273305	212/529 (40%)
		Neur_chan_LBD	26..231	CDD:280998	93/224 (42%)
		Neur_chan_memb	238..481	CDD:280999	112/288 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm11113
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820