DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and chrna6

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_031759256.1	Gene:	chrna6 / 100495287	XenbaseID:	XB-GENE-6033398	Length:	488	Species:	Xenopus tropicalis

Alignment Length:	543	Identity:	214/543 - (39%)
Similarity:	320/543 - (58%)	Gaps:	95/543 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RHCKPLCLLLVLLLL-------CETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRL 78
            |:.|..|.||:.||.       |||      .::|:..||:.||:.||||.|.:|.|:|...:.:
Frog     6 RNEKSFCFLLLTLLAVLKGSLQCET------EEKLFQKLLARYNQHIRPVENVSDPVMVHFEVAI 64

  Fly    79 SQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVV 143
            :||::::..:|||.||:||.|.|.|:|.:|:|.||.|:..:.:|::.||.|||||||||.|::.|
Frog    65 TQLVNVDEVNQILETNLWLRHIWNDYKLQWNPEEYDGIEFMRIPADKIWKPDIVLYNNAVGDFQV 129

  Fly   144 TTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDK 208
            ...:||::.|.|.:.|:|||||||||.:|:.:||||.|.|.||||||:||..:|||..|..|
Frog   130 EGKSKALVKYNGLITWSPPAIFKSSCPMDITFFPFDHQNCSMKFGSWSYDKAKIDLAIIGSK--- 191

  Fly   209 DNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCV 273
                   :|:::::.:.||:|:.....:|:..|.||.|.|.||.::..:||..:|||:|||:||:
Frog   192 -------VDMKDFWENSEWEIVDASGFKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIMPCL 249

  Fly   274 GISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLS 338
            .:|:|:|||||||:|.|||:.||||:|||.|:|.|:|:|.||||||.:||:|:||||||:.|.||
Frog   250 FLSFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLS 314

  Fly   339 VVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMR--VPKDLLRDLAANKINYGLKFSKTK 401
            :|:|:.:||||||.|:||||..|::..|:|||||||:|:  |.|   ::...:|.|......|:
Frog   315 IVVTVFVLNIHYRTPTTHKMPMWVKDVFLKRLPKLLMMKKTVEK---KNRPYSKQNRKKSCEKS- 375

  Fly   402 FGQALMD----EMQ----------MNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGA 452
              ..|:|    |::          |.|...| ..:||.|.|...|
Frog   376 --SELVDSESAEVEQFEDESCYHCMRSKEQS-SRVRRRQQRDSNG-------------------- 417

  Fly   453 LGGGLSTLSGYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDW 517
                                         |.::...||.:.:.::.|:..:::..:|...|:.||
Frog   418 -----------------------------AVQECSSELTEVVDSIQFMAGNIRDHNERKEEEDDW 453

  Fly   518 GFVAMVMDRLFLWLFMIASLVGT 540
            .:||||:||:|||:|::..:|||
Frog   454 KYVAMVIDRVFLWVFILLCVVGT 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	93/218 (43%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	204/510 (40%)
chrna6	XP_031759256.1	LIC	29..481	CDD:273305	206/520 (40%)
chrna6	XP_031759256.1	LGIC_ECD	31..237	CDD:355788	93/215 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2037
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm14085
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.110