Protein Alignment nAChRalpha2 and chrna9

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: XP_012811629.2
• Gene: chrna9 / 100493319
• XenbaseID: XB-GENE-983401
• Length: 494
• Species: Xenopus tropicalis
• Alignment Length: 527
• Identity: 177/527 - (33%)
• Similarity: 271/527 - (51%)
• Gaps: 89/527 - (16%)

  Fly    45 AKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWD 109
            |:.|:.||..:|:..:|||.:....:.|.|.:.|||:.|::.::||||..:|:...|.|...|||
 Frog    32 AQMLFRDLFEDYSNALRPVEDTDKALNVSLQITLSQIKDVDERNQILTAYLWIRLSWYDAYLKWD 96

  Fly   110 PSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVR 174
            ..||.|:..:.:||..:|.|||||||.||.|:.....|..:|.|.||:.|..|||.||||.:||.
 Frog    97 RDEYDGLDSIRIPSNMVWRPDIVLYNKADDEFSEPVNTNVVLRYDGKITWDSPAITKSSCVVDVS 161

  Fly   175 YFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEK 239
            |||||.|.|.:.||||||:|:|:|:         .|.::.| ||.::..:|||::.|:||.::..
 Frog   162 YFPFDNQQCNLTFGSWTYNGNQVDI---------INTMDSG-DLSDFVENVEWEMQGMPAVKNVI 216

  Fly   240 YYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIALCISILLSQT 304
            .|.||:||||||.|.:.|:|::.||..||:||||.||:|:.|.||||||||||::|.:::||:.|
 Frog   217 TYGCCSEPYPDITFTLILKRRSSFYIFNLLIPCVMISFLAPLGFYLPADSGEKVSLGVTVLLALT 281

  Fly   305 MFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKR 369
            :|.|:::|.:| .|.::||:|||.:.||.::..|..:||||:|||...|....:..|.|...:..
 Frog   282 VFQLMVAESMP-PSESVPLIGKYYIATMTMITASTALTIIIMNIHLCGPEAKPIPRWARIVILDY 345

  Fly   370 LPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQMNSGGSSP--DSLRRMQGRVGAG 432
            :.|:.       .:.|:..|             ..:...:....|.||.|  :...:.|
 Frog   346 MSKIF-------FVYDVGEN-------------CTSPQSDSDTKSNGSVPSYEDYEKEQ------ 384

  Fly   433 GCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSLSDVAARKKY------PFELE 491
                                        ..|:.|...|||..:...|:...||.      .:.|:
 Frog   385 ----------------------------EPYSSLGCPLSGSGNFSCDIDTNKKLNGHLGGHYALQ 421

  Fly   492 KAI----------------HNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGT 540
            |.|                :|:.:|.:..:.|...:|:..:|..||.||||.|:|:|.......:
 Frog   422 KEISETHCCAHCNRYRVLTNNIEYITNWYREQKAISAKGIEWKKVAKVMDRFFMWVFFSMVFFMS 486

  Fly   541 FVILGEA 547
            .:|:.:|
 Frog   487 ILIIAQA 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	93/217 (43%)
		LIC	47..544	CDD:273305	174/520 (33%)
chrna9	XP_012811629.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910