DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha2 and chrnb2

DIOPT Version :9

Sequence 1:NP_524482.1 Gene:nAChRalpha2 / 42919 FlyBaseID:FBgn0000039 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_001093684.1 Gene:chrnb2 / 100101688 XenbaseID:XB-GENE-854457 Length:499 Species:Xenopus tropicalis


Alignment Length:527 Identity:222/527 - (42%)
Similarity:316/527 - (59%) Gaps:71/527 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 PLCLLLVLLL-LCETVQANPDAKRLYDDLL--SNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNL 86
            ||...|.||| |..........:||.:.||  |.||:||||.:|.::.|.|:|.:.|:|||.::.
 Frog     8 PLLAALYLLLGLLPGCLGTDTEERLVEHLLDPSRYNKLIRPATNGSEQVTVQLMVSLAQLISVHE 72

  Fly    87 KDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAIL 151
            ::||:||||||..||:|::..|||:|:..:.::.:||:||||||:||||||||.|.|:..:.|::
 Frog    73 REQIMTTNVWLTQEWEDYRLTWDPAEFDDMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVV 137

  Fly   152 HYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGI 216
            .:.|.:.|.||||:||:|:|:|::||||||.|.|||.|||||..::||...|.....|       
 Frog   138 SHDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTELDLVLRSDVASLD------- 195

  Fly   217 DLREYYPSVEWDILGVPAERHEKYYPCCAEP----YPDIFFNITLRRKTLFYTVNLIIPCVGISY 277
               ::.||.||||:.:|..|:|       .|    |.||.::..:|||.||||:||||||:.|:.
 Frog   196 ---DFTPSGEWDIIALPGRRNE-------NPNDSTYVDITYDFIIRRKPLFYTINLIIPCILITS 250

  Fly   278 LSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVIT 342
            |::||||||:|.|||:.||||:||:.|:|.||||:|:|.|||.:||:||||:|||:||..|:|.:
 Frog   251 LAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTS 315

  Fly   343 IIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALM 407
            :.:||:|:|.|:||.|.||::..|:.:||.||.|:.|    |...|.              |.|.
 Frog   316 VCVLNVHHRSPTTHTMPPWVKVVFLDKLPTLLFMKQP----RQNCAR--------------QRLR 362

  Fly   408 DEMQMNSGGSSPDSLRRMQG----RVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPS 468
            .:.|         |..|..|    |.||..|     |...|:.|  |...|..||.      ||.
 Frog   363 QQRQ---------SQERAAGSFFLRDGARSC-----TCYVNQAS--VKKYGAQLSE------LPE 405

  Fly   469 VLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFM 533
            .::|..|....|   ::....|::|:..|.||..||:.:|:..:..:||.:||||:||||||:|:
 Frog   406 GVNGFRDRQGKV---RQCLCGLQEAVDGVRFIADHMKSEDDDQSVSEDWKYVAMVIDRLFLWIFV 467

  Fly   534 IASLVGT 540
            ...:.||
 Frog   468 FVCVFGT 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha2NP_524482.1 LGIC_ECD_nAChR_proto_alpha-like 44..263 CDD:349832 99/224 (44%)
LIC 47..544 CDD:273305 215/504 (43%)
chrnb2NP_001093684.1 LIC 29..479 CDD:273305 215/506 (42%)
LGIC_ECD_nAChR_B2 31..234 CDD:349826 98/219 (45%)
Cys-loop 155..169 CDD:349826 9/13 (69%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm14085
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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