DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and chrnb1l

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001233249.1	Gene:	chrnb1l / 100005295	ZFINID:	ZDB-GENE-060811-1	Length:	486	Species:	Danio rerio

Alignment Length:	523	Identity:	176/523 - (33%)
Similarity:	283/523 - (54%)	Gaps:	69/523 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 QANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDH 104
            :|:...:||.:||..:||..:||.....:.|:|::|:.|.|||.||.|:..:||||::..||.|:
Zfish    15 KASEAERRLLEDLFQDYNLKVRPARTWNERVMVRVGMTLVQLISLNQKNGEMTTNVFMNMEWTDY 79

  Fly   105 KFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSC 169
            :..|:|.:|..:..:.:|...:|.|||.|.||.||::.|......::...|.|.|.||||::|||
Zfish    80 RLSWNPEDYDKIDVVRIPPVKVWRPDIYLINNNDGQFDVALYVNVLVRSDGTVSWLPPAIYRSSC 144

  Fly   170 EIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPA 234
            .|:|.|||||.|.|.|.|.|:|||..::||:: ....|.:...||.||...:..:.||.|...|:
Zfish   145 SIEVAYFPFDWQNCSMVFRSYTYDSSEVDLQY-GLDEDGNELHEIVIDENAFTENGEWQICHKPS 208

  Fly   235 ERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIALCISI 299
            .::.:     .:.|.||.|.:.:.||.|||.:|:|:||:..|.|::.|||||..:|||:.|.||:
Zfish   209 RKNVQ-----DDLYEDITFYLIIERKPLFYVINIIVPCILTSVLAIFVFYLPPGAGEKMTLSISV 268

  Fly   300 LLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRS 364
            |::.|:|.||:::.:|.||||:|::..|::|||:||..||::::::||:|:|.||||.|..|:|.
Zfish   269 LIALTVFMLLLADKVPETSLAIPIIVNYVMFTMILVTFSVILSVVVLNLHHRTPSTHHMPGWVRK 333

  Fly   365 FFIKRLPKLL--LMRVPKDLLRDLAANKINYG-----LKFSKTKFGQALMDEMQMNSGGSSPDSL 422
            .||..||:.|  |...|::.:.:.....:..|     |:.....|.:.:..|:.|...||..:|.
Zfish   334 VFINLLPRYLGVLRPTPEEPVEEEPKENVPMGCLGNSLRPGGEYFIRKINPELVMPWRGSHNEST 398

  Fly   423 RRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSLSDVAARKKY- 486
            .::|                  |||.                             ||     .|
Zfish   399 VKLQ------------------RFSN-----------------------------SD-----NYC 411

  Fly   487 ---PFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGTFVILGEAP 548
               |..|:.||..:.::...:::||..:....||.::|:|:||||||||::.:.:||..:..:|.
Zfish   412 LILPPNLKSAIAAITYMSEQLKKQDVDDTMTDDWQYIAVVLDRLFLWLFVVITTLGTLTMFLDAS 476

  Fly   549 SLY 551
            ..|
Zfish   477 FNY 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	81/218 (37%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	173/507 (34%)
chrnb1l	NP_001233249.1	LIC	11..473	CDD:273305	174/515 (34%)
		Neur_chan_LBD	20..230	CDD:280998	80/215 (37%)
		Neur_chan_memb	237..472	CDD:280999	88/286 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910