DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and chrnb5a

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_009289434.1	Gene:	chrnb5a / 100003503	ZFINID:	ZDB-GENE-090312-169	Length:	494	Species:	Danio rerio

Alignment Length:	523	Identity:	225/523 - (43%)
Similarity:	314/523 - (60%)	Gaps:	70/523 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 CLL-LVLLLLCETVQANPDA-KRLYDDLL--SNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLK 87
            ||| |.||.||.......|| :||.|.||  ..||:||||..|.:..|.:.:.:.|:|||.:|.:
Zfish     9 CLLYLCLLWLCVARSLAADAEERLVDFLLGPERYNKLIRPAVNKSQQVTIGIKVSLAQLISVNER 73

  Fly    88 DQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILH 152
            :||:||||||..||.|::..|||:||.|:.:|.:||.|||||||||||||||.|.|:....|::.
Zfish    74 EQIMTTNVWLTQEWNDYRLVWDPNEYEGIKKLRIPSRHIWLPDIVLYNNADGVYEVSFYCNAVVS 138

  Fly   153 YTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGID 217
            .||.:.|.||||:||:|.|:||.||||||.|.:||.|||||..::||...|....:|
Zfish   139 NTGDIFWLPPAIYKSACAIEVRNFPFDQQNCTLKFRSWTYDRTELDLYLTSDFASRD-------- 195

  Fly   218 LREYYPSVEWDILGVPAERHEKYYPCCAEP-YPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVL 281
              :|.||.||||:.:|..|:|.    .::| |.|:.::..::||.||||:|||||||.|:.|::|
Zfish   196 --DYTPSGEWDIVSLPGRRNED----LSDPTYLDVTYDFVIKRKPLFYTINLIIPCVLITSLAIL 254

  Fly   282 VFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIIL 346
            |||||:|.|||:.||||:||:.|:|.||||:|:|.||||:||:||||:|||:||..|:|.::.:|
Zfish   255 VFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLAVPLIGKYLMFTMVLVTFSIVTSVCVL 319

  Fly   347 NIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQ 411
            |:|:|.||||:|..|::..|:.:||..||||.|         .:.|...:|.:         :.|
Zfish   320 NVHHRSPSTHRMPEWVKRVFLHKLPFFLLMRRP---------GRSNVRERFRR---------KHQ 366

  Fly   412 MNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGL--VGALGGGLSTLSGYNGLPSVLSGLD 474
            ..|..|....| |:.|       :...::....|..|.  ||.|..|
Zfish   367 RKSFSSDTKGL-RLDG-------DSYFLSDDPGRVCGAWRVGDLPEG------------------ 405

  Fly   475 DSLSDVAARKK--YPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASL 537
               |:...|.|  :..::::||..|.||..||:.:|:.....:||.:||||:||||||:|::..:
Zfish   406 ---SEFRQRVKVRHDPDVDEAIEGVRFIAEHMKIEDDDEGIIEDWKYVAMVIDRLFLWIFILVCV 467

  Fly   538 VGT 540
            |||
Zfish   468 VGT 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	104/222 (47%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	215/501 (43%)
chrnb5a	XP_009289434.1	Neur_chan_LBD	20..474	CDD:332142	217/512 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24622
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920