Protein Alignment nAChRalpha1 and CHRNA6

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_004189.1
• Gene: CHRNA6 / 8973
• HGNCID: 15963
• Length: 494
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 228/549 - (41%)
• Similarity: 324/549 - (59%)
• Gaps: 93/549 - (16%)

  Fly     2 GSVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNL 66
            |..|:..||..  |..|.:.....:||:..|.|:||:.||||.|.||.:||...:.::||.:|:.
Human    13 GLCLWLCVFTP--FFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDE 75

  Fly    67 KNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAIL 131
            .||||.||:|:...||||||:|:|.:|.|::||.||::.||.|||||||||.|:::|...|||:|
Human    76 VNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALL 140

  Fly   132 HHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVG-- 194
            .:.|.:.|.||||:||.|.:|:.:||||.|.|.:||||||||...:||           :.:|
Human   141 KYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDL-----------LIIGSK 194

  Fly   195 IDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSV 259
            :|:.|::.:.||:|:.....:::..|:||||.|.||.::..:||..:|||:||||||:.||||:|
Human   195 VDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTV 259

  Fly   260 LVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAV 324
            ||||||||.|||::||||:|||||||.|::.|.||.|||.|||:|:||||||:.||||:|||:.|
Human   260 LVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFV 324

  Fly   325 LNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYD 389
            ||:::|:|.||.|..||:.:|:::||::|.:..|                             .|
Human   325 LNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWP-----------------------------LD 360

  Fly   390 SKRFSGDYGIP----ALPASHRFDLAAAG-----GISAHCFAEPPLPSS------LPLPGADDDL 439
            ..|.:|...:|    ..||..:  ||:.|     ....||.....|.:|      .||....:
Human   361 KTRGTGSDAVPRGLARRPAKGK--LASHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVVE-- 421

  Fly   440 FSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDW 504
                  |.:.||                        |:|..|...:|||:::|:.::.:.||:||
Human   422 ------NSEHSP------------------------EVEDVINSVQFIAENMKSHNETKEVEDDW 456

  Fly   505 KYVAMVLDRMFLWIFAIACVVGTALIILQ 533
            ||||||:||:|||:|.|.||.|||.:.||
Human   457 KYVAMVVDRVFLWVFIIVCVFGTAGLFLQ 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	98/219 (45%)
		LIC	27..530	CDD:455710	220/519 (42%)
		Cys-loop	149..163	CDD:349832	7/13 (54%)
CHRNA6	NP_004189.1	LIC	34..484	CDD:455710	220/523 (42%)
		LGIC_ECD	34..240	CDD:475126	98/216 (45%)