DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and Chrna6

DIOPT Version :9

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:NP_476532.2 Gene:Chrna6 / 81721 RGDID:69281 Length:493 Species:Rattus norvegicus


Alignment Length:540 Identity:223/540 - (41%)
Similarity:325/540 - (60%) Gaps:76/540 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 GSVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNL 66
            |..|:...|:|  |..|.......::|:..|.::|||.||||.|.||.:||...|.::||.:|:.
  Rat    13 GLCLWICGFLA--FFKGSRGCVSEEQLFHTLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDE 75

  Fly    67 KNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAIL 131
            .||||.||:|:...|.||:|.|:|.:|.|::||.||:::||.|||||||||.|:::|...|||:|
  Rat    76 VNQIMETNLWLRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALL 140

  Fly   132 HHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVG-- 194
            .:.|.:.|.||||:||.|.:|:.:||||.|.|.:||||||||...:||           :.:|  
  Rat   141 KYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDL-----------LIIGSK 194

  Fly   195 IDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSV 259
            :|:.|::.:.||:|:.....:::..|:||||.|.||.::..:||..:|||:||||||:.||||:|
  Rat   195 VDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTV 259

  Fly   260 LVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAV 324
            ||||||||.|||::||||:|||||||.|::.|.||.|||.:||:|:||||||:.||||:|||:.|
  Rat   260 LVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFV 324

  Fly   325 LNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERP--KKEEPEEDQPPEVLTDVYHLPPDVDKFVN 387
            ||:::|:|.||.|..||:.:|:|:.|.:|.:.||  |.:|.:..:.|:..|.    .|...||.:
  Rat   325 LNIHYRTPATHTMPKWVKTMFLQVFPSILMMRRPLDKTKEADGVKDPKTHTK----RPAKVKFTH 385

  Fly   388 YDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPG 452
            ...         |.|....|           ||..                       :.:|:||
  Rat   386 RKE---------PKLLKECR-----------HCHK-----------------------SSEIAPG 407

  Fly   453 ----CCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDR 513
                ..||...|..::..|        ::|..|:..:||.:::|:.::.:.||:||||:|||:||
  Rat   408 KRLSQQPAQWVAENSEHPP--------DVEDVIDSVQFITENMKSHNETKEVEDDWKYMAMVVDR 464

  Fly   514 MFLWIFAIACVVGTALIILQ 533
            :|||:|.|.||.||..:.||
  Rat   465 VFLWVFIIVCVFGTVGLFLQ 484

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 Neur_chan_LBD 25..240 CDD:280998 96/216 (44%)
LIC 27..530 CDD:273305 215/510 (42%)
Neur_chan_memb 247..530 CDD:280999 115/288 (40%)
Chrna6NP_476532.2 LIC 34..483 CDD:273305 215/514 (42%)
LGIC_ECD 34..240 CDD:355788 96/216 (44%)
Cys-loop 158..172 CDD:349787 7/13 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 253 1.000 Domainoid score I1995
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 477 1.000 Inparanoid score I1422
OMA 1 1.010 - - QHG45250
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 1 1.000 - - FOG0000583
OrthoInspector 1 1.000 - - mtm12327
orthoMCL 1 0.900 - - OOG6_101158
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X294
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.880

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