Protein Alignment nAChRalpha1 and chrnb3a

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_957514.1
• Gene: chrnb3a / 794401
• ZFINID: ZDB-GENE-040108-1
• Length: 467
• Species: Danio rerio
• Alignment Length: 514
• Identity: 214/514 - (41%)
• Similarity: 295/514 - (57%)
• Gaps: 88/514 - (17%)

  Fly    30 DDLLSN----YNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNP 90
            |.||.|    |.:.:|||.:.:|.:||:.||::|||:||:.|||:||||||:.:||.||||:|||
Zfish    33 DTLLRNLFRGYQKWVRPVLHANDTITVRFGLKISQLVDVDEKNQLMTTNVWLWEEWTDYKLRWNP 97

  Fly    91 DDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEY 155
            :||||:.::.||||.|||||||||.||||.:|.::|||||:...|.::|.|||.|||.|.:||.:
Zfish    98 EDYGGITSIRVPSETIWLPDIVLYENADGRFEGSLMTKAIVRFNGTIMWTPPASYKSACTMDVTF 162

  Fly   156 FPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFY 220
            ||||.|.|.||||||||||.||||         ..::..:|.:|::.:.||:|:.....|..:..
Zfish   163 FPFDRQNCSMKFGSWTYDGTMVDL---------TLVDAYVDRKDFFDNGEWEILNATGQRGSRRD 218

  Fly   221 SCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVF 285
            .....|||  .::..|:|..||||:.|||||:|:|||:|||||||||.|||:||..|:|:|||||
Zfish   219 GIYSYPYL--TYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVF 281

  Fly   286 FLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVT-HRMAPWVQRLFIQIL 349
            .|::.||||.:|..:||:|:||||.|:.||.|::||:.|:||:.||..| |.|||||:.||:|.|
Zfish   282 LLVIEEIIPSSSKVIPLIGEYLLFIMIFVTFSIIVTVFVINVHHRSSATYHPMAPWVKSLFLQRL 346

  Fly   350 PKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAG 414
            |:|||:...              ||.|..|
Zfish   347 PRLLCMRGH--------------TDRYQYP----------------------------------- 362

  Fly   415 GISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEK 479
                                 |.:|.||. |...:..| ...:|....|.:.....:.:...:||
Zfish   363 ---------------------DIELRSPE-LKRGMKKG-QQKSAGGGRAGVKEDENQAWIALLEK 404

  Fly   480 TIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLY 538
            ......:|::|::.:.....|.:|||:||.||||:|||.|....|:||.||...|..::
Zfish   405 ATHSVHYISRHIRKEHFIREVVQDWKFVAQVLDRIFLWAFLTVSVLGTILIFTPALQMF 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	105/215 (49%)
		LIC	27..530	CDD:455710	211/504 (42%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
chrnb3a	NP_957514.1	LIC	9..459	CDD:455710	213/508 (42%)