DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and Htr3a

DIOPT Version :9

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:XP_006243083.1 Gene:Htr3a / 79246 RGDID:61818 Length:488 Species:Rattus norvegicus


Alignment Length:548 Identity:144/548 - (26%)
Similarity:256/548 - (46%) Gaps:82/548 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 LFAAVFIA-----------LHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRL 58
            ||.:|.||           .|..|    .|...||.|.||:||.:.:|||.:......|.:.:.:
  Rat    12 LFLSVLIAQGEGSRRRATQAHSTT----QPALLRLSDHLLANYKKGVRPVRDWRKPTLVSIDVIM 72

  Fly    59 SQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEV 123
            ..:::|:.|||::||.:|..|.|.|..|:|.|:|:..|..|.:|::.||:|||::....|.....
  Rat    73 YAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSP 137

  Fly   124 TIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADS 188
            :| ....:||.|:|....|....:.|.:|:..||||.|.|.:.|.||.:....::: .|.:|.: 
  Rat   138 SI-PYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI-SLWRTPE- 199

  Fly   189 DNIEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVG 253
               ||..|...:....||:::.| ..:.::|.......|.::.|.:.:||:.|||.|:|::|.:.
  Rat   200 ---EVRSDKSIFINQGEWELLGV-FTKFQEFSIETSNSYAEMKFYVVIRRRPLFYAVSLLLPSIF 260

  Fly   254 ISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSV 318
            :..:.::.|.||.||||::|..|::||..:||.:::::.:|.|::..||:|.|.:..|.|:.:|:
  Rat   261 LMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISL 325

  Fly   319 VVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVD 383
            ..||.::.:..:..:...:..|::.|.:..:..|||:    .|:|...:||              
  Rat   326 AETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLLCL----GEQPMAHRPP-------------- 372

  Fly   384 KFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGD 448
              ..:.:.: :.|.....|||           :..||       |.:   |:..||...|  ...
  Rat   373 --ATFQANK-TDDCSGSLLPA-----------MGNHC-------SHV---GSPQDLEKTS--RSR 411

  Fly   449 ISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDR 513
            .||...|..|:.|...|        .:|:..       |...::.:|:...|..||..|..||||
  Rat   412 DSPLPPPREASLAVRGL--------LQELSS-------IRHSLEKRDEMREVARDWLRVGYVLDR 461

  Fly   514 MFLWIFAIACVVGTALIILQAPSLYDQS 541
            :...|:.:| |:..::.::...|::..|
  Rat   462 LLFRIYLLA-VLAYSITLVTLWSIWHYS 488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 Neur_chan_LBD 25..240 CDD:280998 64/214 (30%)
LIC 27..530 CDD:273305 134/502 (27%)
Neur_chan_memb 247..530 CDD:280999 66/282 (23%)
Htr3aXP_006243083.1 LIC 5..482 CDD:273305 142/540 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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