Protein Alignment nAChRalpha1 and Chrna10

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_006229953.1
• Gene: Chrna10 / 64574
• RGDID: 620142
• Length: 492
• Species: Rattus norvegicus
• Alignment Length: 522
• Identity: 179/522 - (34%)
• Similarity: 258/522 - (49%)
• Gaps: 103/522 - (19%)

  Fly    16 ATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQE 80
            |.|.||:    :|:.||.:||...:|||.:....|.|.:.:.|||:||::.:||::|..:|:.||
  Rat    70 AEGRLAH----KLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQE 130

  Fly    81 WNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIY 145
            |.|..|.|:|..||.:|.:.:||..:|.|||||||.||.....:..|..::.|.|.|.|..|||.
  Rat   131 WTDAYLHWDPKAYGDLDAIRIPSRLVWRPDIVLYNKADTQPPASASTNVVVRHDGAVRWDAPAIT 195

  Fly   146 KSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMR 210
            :|.|.:||..||||.|.|.:.|||||:.|:.:|:|....:|         .|.|:..:|||.::.
  Rat   196 RSSCRVDVSAFPFDAQRCGLTFGSWTHGGHQLDVRPRGTSA---------SLADFVENVEWRVLG 251

  Fly   211 VPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLC 275
            :||.|....|.||.|||.|:.|.|.|||:...|..||::|||.||.|:.|.|:||:|||||:||.
  Rat   252 MPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPADSGEKVSLG 316

  Fly   276 ISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPW 340
            :::||:||||.|:|||.:||.. :|||:|||.:.||.:||.|..:||.::|:::..|..|.:..|
  Rat   317 VTVLLALTVFQLILAESMPPAE-SVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPNAHPVPAW 380

  Fly   341 VQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPAS 405
            .:.|.:..|.|.||:.       |..:|
  Rat   381 ARVLLLGHLAKGLCVR-------ERGEP------------------------------------- 401

  Fly   406 HRFDLAAAGGISAHCFAEPPL---PSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSP 467
                          |....||   ||..|.|.      ||:|...:....|...|.....|.::.
  Rat   402 --------------CGQSKPLESAPSLQPPPA------SPAGPCHEPRCLCHQEALLHHIASIAS 446

  Fly   468 TFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIIL 532
            ||....|.:..                      .||||.:|.|:||.||.||....:|.:.::::
  Rat   447 TFRSHRAAQRR----------------------HEDWKRLARVMDRFFLGIFFCMALVMSLIVLV 489

  Fly   533 QA 534
            ||
  Rat   490 QA 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	88/217 (41%)
		LIC	27..530	CDD:455710	173/505 (34%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
Chrna10	XP_006229953.1	LIC	60..476	CDD:455710	174/505 (34%)
		LGIC_ECD	75..281	CDD:475126	89/218 (41%)