Protein Alignment nAChRalpha1 and Htr3b

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_071525.1
• Gene: Htr3b / 58963
• RGDID: 61820
• Length: 437
• Species: Rattus norvegicus
• Alignment Length: 400
• Identity: 103/400 - (25%)
• Similarity: 181/400 - (45%)
• Gaps: 53/400 - (13%)

  Fly     3 SVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLK 67
            |.|..||...|..||....|....||...||..|::.:|||.|.::..||.:.|.:..::||:::
  Rat     6 SCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDVQ 70

  Fly    68 NQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVL---------------YNNA 117
            ||.:.|::|..:.|||..|.||...:..:..:.:|...||.|||::               |.|:
  Rat    71 NQKLKTSMWYREVWNDEFLSWNSSLFDDIQEISLPLSAIWAPDIIINEFVDVERSPDLPYVYVNS 135

  Fly   118 DGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHL 182
            .|         .|.:|      ||..:. |.|.:....||||.|.|.:.|.|..:....:||..|
  Rat   136 SG---------TIRNH------KPIQVV-SACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFL 184

  Fly   183 KQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNL 247
            :...|.:|     |.:.:....||.::.|.:..:.:..|..:  :..|.||:.:||..|.|.|:|
  Rat   185 RNQEDIEN-----DKRSFLNDSEWQLLSVTSTYHIRQSSAGD--FAQIRFNVVIRRCPLAYVVSL 242

  Fly   248 IIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMM 312
            :||.:.:..:.:..||||.:...:|....::|:..|||.:.:::.:|.::....|:|.:....|.
  Rat   243 LIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTSLIGVFFTVCMA 307

  Fly   313 LVTLSVVVTIAVLNVNFRSPVTHRMAPWV----------QRLFIQILPKLLCIERPKKEEPEEDQ 367
            |:.||:..:|.::...:....:.:..|.:          .||::    :..|.|..:....:|.|
  Rat   308 LLVLSLSKSILLIKFLYEERHSEQERPLMCLRGDSDANESRLYL----RAPCAEDTESPVRQEHQ 368

  Fly   368 -PPEVLTDVY 376
             |.:.|.|.:
  Rat   369 VPSDTLKDFW 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	62/229 (27%)
		LIC	27..530	CDD:273305	95/375 (25%)
		Neur_chan_memb	247..530	CDD:280999	30/140 (21%)
Htr3b	NP_071525.1	LIC	30..431	CDD:273305	95/375 (25%)
		Neur_chan_LBD	30..233	CDD:280998	60/225 (27%)
		Neur_chan_memb	242..>313	CDD:280999	18/70 (26%)
		HA-stretch	377..409		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810