Protein Alignment nAChRalpha1 and htr3a

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_009293684.1
• Gene: htr3a / 571641
• ZFINID: ZDB-GENE-071012-5
• Length: 482
• Species: Danio rerio
• Alignment Length: 556
• Identity: 138/556 - (24%)
• Similarity: 247/556 - (44%)
• Gaps: 104/556 - (18%)

  Fly     3 SVLFAAVFIALHFA------------TGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMG 55
            |.|:.|:.|.::..            ||..||....||.:.|.:.|.:.:|||.:.....||.:.
Zfish     4 SALWTALCICMYGTVVDCSVKKLGNNTGRFANATLVRLNEFLSAGYKKGVRPVRDWRQSTTVAID 68

  Fly    56 LRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGN 120
            |.:..:::|:.|||::||.||..|:|.|..|.|:|:::..|..:.:|:.:||:|||::....|..
Zfish    69 LMVYAILNVDEKNQVLTTYVWYRQQWTDEFLMWDPEEFDEVKKISIPTANIWIPDILINEFVDVG 133

  Fly   121 YEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQT 185
            ....| ....:.|.|.|....|....:.|.:::..||:|.|.|.:.|.||.:....:::..::..
Zfish   134 KSPDI-PYVYVGHDGLVSNYKPIQVVTACSLNIYNFPYDVQKCSLTFQSWLHTTKDINITLMRSP 197

  Fly   186 ADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIP 250
            .     .|..|...:....||:::.|.:..| .|....::.|.::.|::.:||:.|||||||::|
Zfish   198 E-----AVKTDKSVFMNQGEWELLHVLSTYN-AFSIDNDDYYAEMKFHVVIRRRPLFYTVNLLLP 256

  Fly   251 CVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVT 315
            .:.:..:.::.||||.||||::|..|::||..:||.:::::.:|.|::..||:|.|.:..|.|:.
Zfish   257 SMFLMVMDIVGFYLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLV 321

  Fly   316 LSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKK----EEPEEDQP---PEVLT 373
            :|:..::.::.:..:..:..|:..||:.|.::....|||| |.||    .....|.|   ...:.
Zfish   322 ISLTESVLIVRLVHKQDLQSRVPQWVKHLVLEKATVLLCI-RNKKICSFRSQGSDLPLYKENNMN 385

  Fly   374 DVYHLPPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAG-GISAHCFAEPPLPSSLPLPGADD 437
            ...|        .|:.|...|.|.|            ...| |:||| .:.||:
Zfish   386 TAIH--------CNHHSCEGSRDSG------------RTLGLGLSAH-ESGPPV----------- 418

  Fly   438 DLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEE 502
                                                   |:..:.....|.|.::.||:...:.:
Zfish   419 ---------------------------------------MDGILREITTIRQFLEKKDESREIAK 444

  Fly   503 DWKYVAMVLD----RMF-LWIFAIACVVGTALIILQ 533
            :|..|..|||    |:: |.:.|....:|:...|.|
Zfish   445 EWLQVGYVLDILLFRVYLLTVLAYGITLGSLWSIWQ 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	57/214 (27%)
		LIC	27..530	CDD:273305	128/515 (25%)
		Neur_chan_memb	247..530	CDD:280999	65/295 (22%)
htr3a	XP_009293684.1	LIC	21..479	CDD:273305	132/536 (25%)
		Neur_chan_LBD	40..246	CDD:280998	57/212 (27%)
		Neur_chan_memb	253..479	CDD:280999	65/297 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810