Protein Alignment nAChRalpha1 and CHRNA10

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_065135.2
• Gene: CHRNA10 / 57053
• HGNCID: 13800
• Length: 450
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 178/510 - (34%)
• Similarity: 257/510 - (50%)
• Gaps: 90/510 - (17%)

  Fly    25 AKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWN 89
            |.:|:.||.:||...:|||.:....|.|.:.:.|||:||::.:||::|..:|:.|||.|..|:|:
Human    30 ALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWD 94

  Fly    90 PDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVE 154
            |:.|||:|.:.:||..:|.|||||||.||.....:..|..:|.|.|.|.|..|||.:|.|.:||.
Human    95 PNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVA 159

  Fly   155 YFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKF 219
            .||||.|.|.:.|||||:.|:.:|:|.....|         .|.|:..:|||.::.:||.|....
Human   160 AFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAA---------SLADFVENVEWRVLGMPARRRVLT 215

  Fly   220 YSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTV 284
            |.||.|||.|:.|.|.|||:...|..||::|||.||.|:.|.|:||:|||||:||.:::||:|||
Human   216 YGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTV 280

  Fly   285 FFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQIL 349
            |.|||||.:||.. :|||:|||.:.||.:||.|..:||.::|:::..|....:..|.:.|.:..|
Human   281 FQLLLAESMPPAE-SVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHL 344

  Fly   350 PKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAG 414
            .:.||: |.:.|...:.:|||:
Human   345 ARGLCV-RERGEPCGQSRPPEL------------------------------------------- 365

  Fly   415 GISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEK 479
                     .|.|.            ||.|       |..|.|        .|..|.......|.
Human   366 ---------SPSPQ------------SPEG-------GAGPPA--------GPCHEPRCLCRQEA 394

  Fly   480 TIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQA 534
            .:.....||...::....:...||||.:|.|:||.||.||....:|.:.|:::||
Human   395 LLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQA 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	91/216 (42%)
		LIC	27..530	CDD:455710	174/502 (35%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
CHRNA10	NP_065135.2	LGIC_ECD	30..236	CDD:475126	91/214 (43%)
		LGIC_TM_cation	239..>324	CDD:349853	47/85 (55%)
		TM1 helix	239..261	CDD:349853	11/21 (52%)
		Neur_chan_memb	243..434	CDD:460753	79/271 (29%)
		TM2 helix	269..290	CDD:349853	13/20 (65%)
		TM3 helix	300..322	CDD:349853	9/21 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..380		11/95 (12%)