DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha1 and chrnb5b

DIOPT Version :9

Sequence 1:	NP_001262916.1	Gene:	nAChRalpha1 / 42918	FlyBaseID:	FBgn0000036	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_017214550.1	Gene:	chrnb5b / 569662	ZFINID:	ZDB-GENE-120809-5	Length:	475	Species:	Danio rerio

Alignment Length:	509	Identity:	214/509 - (42%)
Similarity:	290/509 - (56%)	Gaps:	97/509 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FIALHFATGGLANPDAKRLYDDLLS--NYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMT 72
            |:||..||...|..: :||.:.|||  .||:||||..|.|.::|:.:.:.|:|||.||.:.||||
Zfish    11 FVALTMATVWCAEVE-ERLVNYLLSPDRYNKLIRPAVNKSQQVTIAIQVSLAQLISVNEREQIMT 74

  Fly    73 TNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKV 137
            ||.|:.|.||||:|.|:|::|.|:..:.:||:|||||||||||||||.|||:..:.|::.:.|:|
Zfish    75 TNCWLTQVWNDYRLMWDPEEYEGMRKVRLPSQHIWLPDIVLYNNADGTYEVSFYSNAVVSNNGEV 139

  Fly   138 VWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYI 202
            .|.|||||||.|:|:|..||||:|.|.:||.|||||...:||..|...|..|         |:..
Zfish   140 AWLPPAIYKSACKIEVRDFPFDQQNCTLKFRSWTYDHTEIDLILLSDFASRD---------DFKP 195

  Fly   203 SVEWDIMRVPAVRNEKFYSCCEEP----YLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFY 263
            |.||||:.:|..:|       |:|    ||||.::..:|||.||||:|||||||.|:.|::||||
Zfish   196 SGEWDIVSLPGRKN-------EDPNDVTYLDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFY 253

  Fly   264 LPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVN 328
            ||||.||||:||||:||:||||.||:::|:|||||.|||:||||:|||:|||.|:|.::.||||:
Zfish   254 LPSDCGEKITLCISVLLALTVFLLLISKIVPPTSLAVPLIGKYLMFTMVLVTFSIVTSVCVLNVH 318

  Fly   329 FRSPVTHRMAPWVQRLFIQILPKLLCIERP------------KKEEPEEDQPPEVLTDVYHLPPD 381
            .|||.||.|..||:..|:..||..|.:.||            .::....|.|.:...|    ..|
Zfish   319 HRSPSTHSMPKWVKYYFLVRLPAFLFMRRPGESNKRDRFRRKHQQHSSSDVPVKSEAD----EAD 379

  Fly   382 VDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLN 446
            ...|||.||....|               ..||                       :|...|.|.
Zfish   380 STFFVNEDSANHIG---------------WRAG-----------------------ELQENSELR 406

  Fly   447 GDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESV 500
            ..::..|                    :.:||:.::|.|:||..:|::|..|.|
Zfish   407 KRMAVKC--------------------SADMEEAVKGVRYIADKMKSEDDDEGV 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	105/220 (48%)
		LIC	27..530	CDD:273305	208/492 (42%)
		Neur_chan_memb	247..530	CDD:280999	97/266 (36%)
chrnb5b	XP_017214550.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	234	1.000	Domainoid score	I2314
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920