Protein Alignment nAChRalpha1 and chrnb5b

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_073778294.1
• Gene: chrnb5b / 569662
• ZFINID: ZDB-GENE-120809-5
• Length: 487
• Species: Danio rerio
• Alignment Length: 542
• Identity: 234/542 - (43%)
• Similarity: 316/542 - (58%)
• Gaps: 97/542 - (17%)

  Fly    10 FIALHFATGGLANPDAKRLYDDLLS--NYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMT 72
            |:||..||...|..: :||.:.|||  .||:||||..|.|.::|:.:.:.|:|||.||.:.||||
Zfish    11 FVALTMATVWCAEVE-ERLVNYLLSPDRYNKLIRPAVNKSQQVTIAIQVSLAQLISVNEREQIMT 74

  Fly    73 TNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKV 137
            ||.|:.|.||||:|.|:|::|.|:..:.:||:|||||||||||||||.|||:..:.|::.:.|:|
Zfish    75 TNCWLTQVWNDYRLMWDPEEYEGMRKVRLPSQHIWLPDIVLYNNADGTYEVSFYSNAVVSNNGEV 139

  Fly   138 VWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYI 202
            .|.|||||||.|:|:|..||||:|.|.:||.|||||...:||..|...|..|         |:..
Zfish   140 AWLPPAIYKSACKIEVRDFPFDQQNCTLKFRSWTYDHTEIDLILLSDFASRD---------DFKP 195

  Fly   203 SVEWDIMRVPAVRNEKFYSCCEEP----YLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFY 263
            |.||||:.:|..:|       |:|    ||||.::..:|||.||||:|||||||.|:.|::||||
Zfish   196 SGEWDIVSLPGRKN-------EDPNDVTYLDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFY 253

  Fly   264 LPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVN 328
            ||||.||||:||||:||:||||.||:::|:|||||.|||:||||:|||:|||.|:|.::.||||:
Zfish   254 LPSDCGEKITLCISVLLALTVFLLLISKIVPPTSLAVPLIGKYLMFTMVLVTFSIVTSVCVLNVH 318

  Fly   329 FRSPVTHRMAPWVQRLFIQILPKLLCIERP------------KKEEPEEDQPPEVLTDVYHLPPD 381
            .|||.||.|..||:..|:..||..|.:.||            .::....|.|.:...|    ..|
Zfish   319 HRSPSTHSMPKWVKYYFLVRLPAFLFMRRPGESNKRDRFRRKHQQHSSSDVPVKSEAD----EAD 379

  Fly   382 VDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLN 446
            ...|||.||....|               ..||                       :|...|.|.
Zfish   380 STFFVNEDSANHIG---------------WRAG-----------------------ELQENSELR 406

  Fly   447 GDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVL 511
            ..::..|                    :.:||:.::|.|:||..:|::|..|.:.|||||||||:
Zfish   407 KRMAVKC--------------------SADMEEAVKGVRYIADKMKSEDDDEGIIEDWKYVAMVI 451

  Fly   512 DRMFLWIFAIACVVGTALIILQ 533
            ||:|||||.:.||.||..:.:|
Zfish   452 DRLFLWIFVLVCVAGTIGLFMQ 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	106/223 (48%)
		LIC	27..530	CDD:455710	227/520 (44%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
chrnb5b	XP_073778294.1	None