Protein Alignment nAChRalpha1 and chrna9a

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_021326868.1
• Gene: chrna9a / 568807
• ZFINID: ZDB-GENE-090312-63
• Length: 580
• Species: Danio rerio
• Alignment Length: 601
• Identity: 200/601 - (33%)
• Similarity: 305/601 - (50%)
• Gaps: 101/601 - (16%)

  Fly     3 SVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLK 67
            |:|..|||.|        ....|::|.:||:..|:..:|||.:....|.|.:.:.|||:.|::.:
Zfish    11 SLLLHAVFSA--------QGRFAQKLLNDLMEGYSNALRPVEDTDKALNVTLQITLSQIKDMDER 67

  Fly    68 NQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNAD-----GNYEVTIMT 127
            ||::||.:||.|.|:|..|.|:.::|.|::.:.:||..:|.||||||||||     |..:    |
Zfish    68 NQVLTTYLWVRQIWHDAYLSWDKEEYDGLEVIRIPSNLVWRPDIVLYNNADEEDSSGPPD----T 128

  Fly   128 KAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIE 192
            ..:|.:.|::.|..|||.||.|::||.|||||.|.|.:.||||||:|..||:        :..:|
Zfish   129 NVVLRYNGEITWDSPAITKSSCKVDVSYFPFDSQECNLTFGSWTYNGNQVDI--------AMGME 185

  Fly   193 VGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFL 257
            .| ||.|:..:|||:...:|||:|...|.||.:||.||.:.:.|:|::.||..||::||..||||
Zfish   186 SG-DLSDFVDNVEWECHGMPAVKNVIMYGCCSDPYPDITYTVLLKRRSSFYIFNLLLPCFLISFL 249

  Fly   258 SVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTI 322
            :.|.||||:|||||:||.:::||:||||.|::||.:|| |.:|||:|||.:.||.::|.|..:||
Zfish   250 APLGFYLPADSGEKVSLGVTVLLALTVFQLMVAESMPP-SESVPLIGKYYIATMTMITASTSLTI 313

  Fly   323 AVLNVNF----RSPVTHRMAPWVQRLFIQILPKLLCIERPKKE--EPEEDQPP--------EVLT 373
            .::|::|    ..||.|    |.:.|.|..:.|:..:....:.  .||.|:.|        .:..
Zfish   314 FIMNIHFCGAEAKPVPH----WAKVLIIDYMSKIFFVYEVGENCTTPESDRGPFFSEDPLASLER 374

  Fly   374 DVY---------HLPPDV-DKFVNY---DSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPP 425
            |.|         ||...: .:|..|   |.:..:|.:...:....||.:.......|::   .|.
Zfish   375 DGYFDKGFYEDCHLDERIRSQFNGYSHRDHRHGNGYHHKNSSYRQHRHEQQRRTRSSSN---SPV 436

  Fly   426 LPSS----------------LPLPG----ADDDLFSPSGLNG---DISPGCCPAAAAAAAADLSP 467
            ..||                |||..    .|.::..|..:||   |...|.............|.
Zfish   437 RQSSHHPKYTHFIGRDGSEKLPLTSQEKLKDSEISIPEKINGYTYDQGNGYLNGVGYLHDNGYSK 501

  Fly   468 TFEKPYAREMEKTIEGS--------------RFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWI 518
            ||.   |....||..|:              .:||...:.:...::...:||.||.|:||.|:|:
Zfish   502 TFG---ADSYNKTTTGTGCVCGKHQKLVRNIEYIANCFREQRGHQAKGAEWKKVAKVMDRFFMWV 563

  Fly   519 FAIACVVGTALIILQA 534
            |.|...:.:.|::.:|
Zfish   564 FFIMVFLMSILVLAKA 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	90/219 (41%)
		LIC	27..530	CDD:273305	191/571 (33%)
		Neur_chan_memb	247..530	CDD:280999	99/346 (29%)
chrna9a	XP_021326868.1	Neur_chan_LBD	25..231	CDD:308532	89/218 (41%)
		Neur_chan_memb	239..>367	CDD:308533	56/132 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910