Protein Alignment nAChRalpha1 and chrna11

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001038562.1
• Gene: chrna11 / 566141
• ZFINID: ZDB-GENE-060503-606
• Length: 589
• Species: Danio rerio
• Alignment Length: 615
• Identity: 202/615 - (32%)
• Similarity: 311/615 - (50%)
• Gaps: 123/615 - (20%)

  Fly    12 ALHFATGGLA--------NPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKN 68
            :|.|...|::        .|..:.|..:||.:|||:.|||.|:|..|||.:.:.|.|::||:.||
Zfish     4 SLAFTLCGISALIQVSVQGPYQRTLLKNLLKDYNRMERPVANDSQPLTVFLSMSLIQIMDVDEKN 68

  Fly    69 QIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHH 133
            |::|||:|:...|.|:.|:||..:|.||..|...::.:|.|||:|||:||..::.|..:..:::.
Zfish    69 QVLTTNIWLNMHWYDHYLQWNQSEYPGVKNLRFTTDQVWTPDILLYNSADDKFDSTFKSNVVVNS 133

  Fly   134 TGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQ 198
            :|...:.||.|:.|.|.:||.:||||.|.|.:||||||:||:::||:..:           .|:.
Zfish   134 SGYCNYLPPGIFMSTCNVDVRWFPFDIQKCELKFGSWTFDGWLLDLQMNE-----------ADIS 187

  Fly   199 DYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFY 263
            .|..:.|||::.||..|||.||.||:|||.|:.|.:|:||:||:|.:||:||||.:|.:::|:|.
Zfish   188 GYMPNGEWDLVGVPGTRNELFYDCCKEPYPDVTFVVTIRRRTLYYALNLLIPCVLLSSMTLLIFL 252

  Fly   264 LPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVN 328
            ||:||||||||.|::|||||||.||:|||:|.||.::||:|:|....|::|.:||:.|:.||..:
Zfish   253 LPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSIPLIGQYFASIMIIVGMSVIATVVVLQYH 317

  Fly   329 FRSPVTHRMAPWVQRLFIQILPKLLCIERP-KKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKR 392
            ...|....|..|||.:.:|.:...|.::|| :.|:||.             ||.........|..
Zfish   318 HHDPNGGNMPKWVQLVLLQWVAWFLRMKRPGESEDPER-------------PPCAPHLRRCSSGS 369

  Fly   393 FSGDYGIPALPASHRFDL--------------------AAAGGISAH------------------ 419
            .||  .:|..|.|...||                    |||.|.:.|
Zfish   370 QSG--SLPNAPGSASADLHHHHISSTLHPLHPQSLLQAAAAAGHTHHLHNQTNSANNNGNLLYIG 432

  Fly   420 ----------------------------CFAEPPLPSSLPLPGADDDLFSP----------SGLN 446
                                        ....||:..|.|.|.......||          :|..
Zfish   433 FSSLDEASPPALLADSVQRNSMSGGPRPTVVSPPVVGSSPPPHLPSQFCSPPPPPTPNLEATGCP 497

  Fly   447 GDIS--PGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAM 509
            ..:|  .|.|..:..:...|          .:::..:|..|::|...:.:|:.|||.|.||:.|.
Zfish   498 STVSGGGGGCSCSGTSGGGD----------PQLQAILEEVRYVADRFRGQDENESVTEQWKFAAA 552

  Fly   510 VLDRMFLWIFAIACVVGTALIILQAPSLYD 539
            |:||:.|..|::..::.|..|::.||:..:
Zfish   553 VIDRLCLVAFSVFNIICTISILMSAPNFVE 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	90/214 (42%)
		LIC	27..530	CDD:273305	195/581 (34%)
		Neur_chan_memb	247..530	CDD:280999	101/361 (28%)
chrna11	NP_001038562.1	LIC	2..577	CDD:273305	200/608 (33%)
		Neur_chan_LBD	25..229	CDD:280998	90/214 (42%)
		Neur_chan_memb	236..573	CDD:280999	101/361 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910