Protein Alignment nAChRalpha1 and chrnb2

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_005169811.1
• Gene: chrnb2 / 561906
• ZFINID: ZDB-GENE-070821-3
• Length: 543
• Species: Danio rerio
• Alignment Length: 562
• Identity: 234/562 - (41%)
• Similarity: 320/562 - (56%)
• Gaps: 78/562 - (13%)

  Fly     9 VFIALHFATGGLANPDAKRLYDDLL--SNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIM 71
            :|..|.....|......:||.:.||  ::||:||||..|.|:.:||::.:.|:|||.|:.:.|||
Zfish     7 LFCILAIVKSGYGADTEERLVEHLLNPAHYNKLIRPATNGSEVVTVQLMVSLAQLISVHEREQIM 71

  Fly    72 TTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGK 136
            |||||:.|||.||:|.|:|:::.|:..:.:||:||||||:||||||||.|||:..:.|::.:.|.
Zfish    72 TTNVWLTQEWQDYRLTWSPEEFDGMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGS 136

  Fly   137 VVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYY 201
            |.|.|||||||.|:|:|::||||:|.|.:.|.|||||...|||......|..|         |:.
Zfish   137 VFWLPPAIYKSACKIEVKHFPFDQQNCTLSFRSWTYDRTEVDLVLRADVASMD---------DFT 192

  Fly   202 ISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPS 266
            .|.||||:.:|..|||   :..:..|:||.::..:|||.||||:|||||||.|:.|::|||||||
Zfish   193 PSGEWDIIALPGRRNE---NPSDPTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPS 254

  Fly   267 DSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRS 331
            |.|||::||||:||:||||.||:::|:|||||.|||:||||:|||:|||.|:|.::.||||:.||
Zfish   255 DCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRS 319

  Fly   332 PVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGD 396
            |.||.|.|||:.:|:..||.||.:.:|:.....:                     ....:|.:.:
Zfish   320 PTTHTMPPWVKLVFLNKLPALLFMRQPRNSSERQ---------------------RLRQRRRANE 363

  Fly   397 Y---GIPALPASHRFDLAAAGGISAH--------CFAEPPLPSSL--PLPGADDDLFSPSGLNG- 447
            .   |...|.|.....|..:|..|..        |:.........  .|.|......|..||||
Zfish   364 QQEGGRGGLAAGLMAGLGLSGSSSGSKENNEACTCYVNRASVKQFGAELGGGGGGGGSTDGLNGI 428

  Fly   448 -------------DISPGCCP--------AAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHV 491
                         .:.....|        ....|..|...|.|        |:.::|.||||.|:
Zfish   429 REGGRETREGGANPLQGSALPRGKQQPPTVLTQALLAQACPGF--------EEAVDGVRFIANHM 485

  Fly   492 KNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQ 533
            |::|...||.|||||||||:||:|||||...||.||..:.||
Zfish   486 KSEDDDRSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQ 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	101/216 (47%)
		LIC	27..530	CDD:273305	229/539 (42%)
		Neur_chan_memb	247..530	CDD:280999	122/317 (38%)
chrnb2	XP_005169811.1	LIC	4..526	CDD:273305	232/559 (42%)
		Neur_chan_LBD	23..228	CDD:280998	101/216 (47%)
		Neur_chan_memb	235..525	CDD:280999	122/318 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	234	1.000	Domainoid score	I2314
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H595
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820