Protein Alignment nAChRalpha1 and chrna10a

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_021337092.1
• Gene: chrna10a / 556507
• ZFINID: ZDB-GENE-060503-725
• Length: 532
• Species: Danio rerio
• Alignment Length: 545
• Identity: 183/545 - (33%)
• Similarity: 288/545 - (52%)
• Gaps: 78/545 - (14%)

  Fly    25 AKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWN 89
            |::|.:||.:||...:|||.:..|.|.|.:.:.|||:||::.:|||:|..:|:.|.|.|..|.||
Zfish    30 AQKLLNDLFNNYTSALRPVEDTEDILNVTLQITLSQIIDMDERNQILTAYLWIRQVWIDKYLTWN 94

  Fly    90 PDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVE 154
            .::|.|:||:.:|..::|.|||||||:||.::..|:.|..::.|.|:::|..|||.||.|::||.
Zfish    95 KENYDGLDTIRIPGSYVWRPDIVLYNSADDHFTSTMDTNVVIRHDGQIMWDAPAITKSSCKVDVS 159

  Fly   155 YFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKF 219
            :||||.|.|.:.:|||||:|..:|:.:..::|         ||.|...:|||:::.:||.||...
Zfish   160 FFPFDAQQCRLTYGSWTYNGNQLDILNAMESA---------DLADLVDNVEWEVLGMPAKRNIIL 215

  Fly   220 YSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTV 284
            |.||.:||.|:.:.|.|:|:..||..||:||||.||||:.|.||||:|||||:||.::::|:|||
Zfish   216 YGCCADPYPDVTYTLKLKRRASFYVFNLLIPCVMISFLAPLGFYLPADSGEKVSLGVTVMLALTV 280

  Fly   285 FFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQIL 349
            |.||:|||:|| |..|||:|||.:.||.::|.|..:||.|:|::...|....:..|.::..:|.|
Zfish   281 FQLLVAEIMPP-SENVPLIGKYYIATMTMITASTALTIFVMNIHHCGPDAKPVPDWAKKFILQYL 344

  Fly   350 PKLLCI---------ERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPAS 405
            .::..:         .:|:|.:|:..:|.             |...|.:.:....|:       .
Zfish   345 ARICFVYEVGENCMTPQPEKPDPQPQKPQ-------------DCNCNMNGQAGKDDF-------V 389

  Fly   406 HRFDLAAAGGISAHCFAEPPLPSSLPLPGADD--DLFSPSGLNGDISPGC--------------C 454
            .:||.....       ..|.|     |...:|  .:.||:...|. .|.|              |
Zfish   390 FKFDRNQEA-------TSPKL-----LEDREDMSQILSPACSLGK-HPTCRYGVWKEGVFMSMDC 441

  Fly   455 PAAAA----------AAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAM 509
            ...||          ....|....|:.....:.:..:....::|...:::........:||.||.
Zfish   442 GDGAAETGKPIGRGQEGCRDHDSGFKSQCKCDQQHLLRNIEYVANCYRDQRATARRTGEWKKVAK 506

  Fly   510 VLDRMFLWIFAIACVVGTALIILQA 534
            ||||.|:|:|.|.....:.||:.:|
Zfish   507 VLDRFFMWLFFIMVFFMSLLIMGKA 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	89/216 (41%)
		LIC	27..530	CDD:455710	179/537 (33%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
chrna10a	XP_021337092.1	LIC	31..422	CDD:455710	158/432 (37%)
		LGIC_ECD_nAChR_A10	55..235	CDD:349824	78/188 (41%)
		Cys-loop	154..168	CDD:349824	8/13 (62%)