Protein Alignment nAChRalpha1 and chrna6

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001036149.1
• Gene: chrna6 / 555747
• ZFINID: ZDB-GENE-090312-91
• Length: 512
• Species: Danio rerio
• Alignment Length: 539
• Identity: 227/539 - (42%)
• Similarity: 321/539 - (59%)
• Gaps: 94/539 - (17%)

  Fly    27 RLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPD 91
            ||:..|...||:.||||.|.||.:||:..:.:|||:.|:..||||.||:|:...||||||||:|.
Zfish    29 RLFRRLFRRYNQFIRPVENVSDPVTVEFEVSISQLVKVDEVNQIMETNLWLRHIWNDYKLKWSPA 93

  Fly    92 DYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYF 156
            ::.|::.:.|||..||.|||||||||.|::.|...|||:|...|.:.|.||||:||.|.:|:.||
Zfish    94 EFDGIEFIRVPSNKIWRPDIVLYNNAVGDFLVEDKTKALLKFDGTITWVPPAIFKSSCPMDITYF 158

  Fly   157 PFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVG--IDLQDYYISVEWDIMRVPAVRNEKF 219
            |||.|.|.|||||||||...:||           :.:|  ::|:|::.|.||:|:..|..:::..
Zfish   159 PFDYQNCSMKFGSWTYDKAKIDL-----------VLIGSKVNLKDFWESGEWEIIDAPGYKHDIK 212

  Fly   220 YSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTV 284
            |:||||.|.||.::..:||..||||:||||||:.||||:|||||||||.|||::||||:||||||
Zfish   213 YNCCEEIYPDITYSFYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTV 277

  Fly   285 FFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQIL 349
            |.|::.|.||.|||.:||:|:||||||:.||||:|:|:.||||::|:|:||.|..||..:|::.|
Zfish   278 FLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPMTHTMPSWVHTVFLRAL 342

  Fly   350 PKLLCIERP----------------------------KKEEPEEDQPPEVLTDVYHLPPDVDKFV 386
            |:::.:.||                            ||.:....|...:
Zfish   343 PRIMLMRRPLDLSESSGKGGLETGGSSGTGAGRGGEGKKRKNSGSQQGAM--------------- 392

  Fly   387 NYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISP 451
              :|..| |: |..||...       .||...|           ||..|.:      |..|.:|.
Zfish   393 --NSLEF-GE-GKAALEGK-------KGGCPCH-----------PLKEATE------GDCGKVSR 429

  Fly   452 GCCPAA--AAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRM 514
            ...|.|  ...|.:.:||        |:::.||..::||:::::::|.:.||:||||||||:||:
Zfish   430 QLSPQAINTVVAFSVVSP--------EIKQAIESVKYIAENMRSRNKAKEVEDDWKYVAMVIDRI 486

  Fly   515 FLWIFAIACVVGTALIILQ 533
            |||:|.:.||:||..:.||
Zfish   487 FLWVFVLVCVLGTLGLFLQ 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	101/216 (47%)
		LIC	27..530	CDD:455710	225/534 (42%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
chrna6	NP_001036149.1	LIC	38..504	CDD:455710	222/527 (42%)
		LGIC_ECD	38..233	CDD:475126	98/205 (48%)