DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha1 and chrna5

DIOPT Version :9

Sequence 1:	NP_001262916.1	Gene:	nAChRalpha1 / 42918	FlyBaseID:	FBgn0000036	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001017885.1	Gene:	chrna5 / 550584	ZFINID:	ZDB-GENE-050417-440	Length:	466	Species:	Danio rerio

Alignment Length:	531	Identity:	209/531 - (39%)
Similarity:	304/531 - (57%)	Gaps:	110/531 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPD 91
            :|:..|.|||.:.:||:.:.:..:.||.||.:|||:||:.|||:||||||::|||.|.||:|:||
Zfish    38 KLFKHLFSNYQKWVRPIEDLNTTIQVKFGLAISQLVDVDEKNQLMTTNVWMKQEWTDLKLRWDPD 102

  Fly    92 DYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYF 156
            .|.|:.::.|||:.||:||||||:|||||:|.|: |||::...|.:.|.|||.|||.|.|||.:|
Zfish   103 HYLGITSIRVPSDSIWIPDIVLYDNADGNFEATV-TKAVVRFDGTISWTPPANYKSACTIDVTFF 166

  Fly   157 PFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEK--- 218
            |||.|.|.||||||||||..||:  |.:       :|.:|.:||:.:.||:|::....|..:
Zfish   167 PFDLQNCSMKFGSWTYDGSQVDI--LLE-------DVHVDKRDYFDNGEWEIVKATGNRGLRRDG 222

  Fly   219 -FYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSL 282
             |:      |..|.::..:||..||||:.|||||:|:|||:||||||||:.|||||||.|:|:||
Zfish   223 TFF------YPSITYSFIIRRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNGGEKISLCTSVLVSL 281

  Fly   283 TVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHR-MAPWVQRLFI 346
            |||.|::.||||.:|..:||:|:||:|||:.||||:|:|:..:|::.||..||. |||||:|:|:
Zfish   282 TVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIVITVFAINIHHRSSSTHHSMAPWVRRIFL 346

  Fly   347 QILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSG-DYGIPALPASHRFDL 410
            ..||:|||:.                       ..||::......|..| .||......:::.|
Zfish   347 HHLPRLLCMR-----------------------SHVDRYATSAGTRTGGLGYGKSLSQDTNQLD- 387

  Fly   411 AAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAR 475
                       ||                                                   .
Zfish   388 -----------AE---------------------------------------------------H 390

  Fly   476 EMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLYDQ 540
            .::..:|..|:|.:||..:::...|.:|||:||.||||:|||.|.:..::|:||:.:  |.:|..
Zfish   391 NLQAALESIRYITRHVVKENEVREVVQDWKFVAQVLDRVFLWAFLLVSLLGSALLFI--PVIYKW 453

  Fly   541 SQPIDILYSKI 551
            :..|...|::|
Zfish   454 ASIIVPSYAEI 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	101/216 (47%)
		LIC	27..530	CDD:273305	203/508 (40%)
		Neur_chan_memb	247..530	CDD:280999	98/284 (35%)
chrna5	NP_001017885.1	LIC	12..448	CDD:273305	204/513 (40%)
		Neur_chan_LBD	36..239	CDD:280998	101/216 (47%)
		Neur_chan_memb	246..446	CDD:280999	99/285 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830