DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and Chrna10

DIOPT Version :9

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:NP_001074893.1 Gene:Chrna10 / 504186 MGIID:3609260 Length:447 Species:Mus musculus


Alignment Length:532 Identity:183/532 - (34%)
Similarity:263/532 - (49%) Gaps:104/532 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 FIALHF-------ATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLK 67
            |:.|.|       |.|.||:    :|:.||.:||...:|||.:....|.|.:.:.|||:||::.:
Mouse    12 FLLLLFLPAECLGAEGRLAH----KLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDER 72

  Fly    68 NQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILH 132
            ||::|..:|:.|||.|..|.|:|..||.:|.:.:||..:|.|||||||.||.....:..|..::.
Mouse    73 NQVLTLYLWIRQEWTDAYLHWDPKAYGDLDAIRIPSSLVWRPDIVLYNKADTQPPASASTNVVVR 137

  Fly   133 HTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDL 197
            |.|.|.|..|||.:|.|.:||..||||.|.|.:.|||||:.|:.:|:|....:|         .|
Mouse   138 HDGAVRWDAPAITRSSCRVDVSAFPFDAQRCGLTFGSWTHGGHQLDVRPRGTSA---------SL 193

  Fly   198 QDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVF 262
            .|:..:|||.::.:||.|....|.||.|||.|:.|.|.|||:...|..||::|||.||.|:.|.|
Mouse   194 ADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAF 258

  Fly   263 YLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNV 327
            :||:|||||:||.:::||:||||.|:|||.:||.. :|||:|||.:.||.:||.|..:||.::|:
Mouse   259 HLPADSGEKVSLGVTVLLALTVFQLILAESMPPAE-SVPLIGKYYMATMTMVTFSTALTILIMNL 322

  Fly   328 NFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKR 392
            ::..|..|.:..|.:.|.:..|.|.||: |.:.|...:.:|.|....:.  ||            
Mouse   323 HYCGPNAHPVPAWARVLLLGHLAKGLCV-RERGEPCGQSKPLESAPSLQ--PP------------ 372

  Fly   393 FSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAA 457
                .|.||.|...                    |..|                      |...|
Mouse   373 ----AGPPAGPCHE--------------------PRCL----------------------CHQEA 391

  Fly   458 AAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIA 522
            .....|.::.||....|.:..                      .||||.:|.|:||.||.||...
Mouse   392 LLHHVASIAGTFRSHRAAQRR----------------------HEDWKRLARVMDRFFLGIFFCM 434

  Fly   523 CVVGTALIILQA 534
            .:|.:.|:::||
Mouse   435 ALVMSLLVLVQA 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 Neur_chan_LBD 25..240 CDD:280998 88/214 (41%)
LIC 27..530 CDD:273305 173/502 (34%)
Neur_chan_memb 247..530 CDD:280999 83/282 (29%)
Chrna10NP_001074893.1 LGIC_ECD 30..236 CDD:355788 89/218 (41%)
LGIC_TM_cation 239..>324 CDD:349853 46/85 (54%)
TM1 helix 239..261 CDD:349853 11/21 (52%)
Neur_chan_memb 243..437 CDD:367256 82/277 (30%)
TM2 helix 269..290 CDD:349853 12/20 (60%)
TM3 helix 300..322 CDD:349853 9/21 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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