Protein Alignment nAChRalpha1 and ort

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Alignment Length: 427
• Identity: 85/427 - (19%)
• Similarity: 149/427 - (34%)
• Gaps: 140/427 - (32%)

  Fly     4 VLFAAVFIALHFATG----GLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDV 64
            :|........|:|.|    .||..|.  |.:| :..|::: ||.........|...:.:..|..:
  Fly     7 ILVICTICMKHYAKGEFQQSLAITDI--LPED-IKRYDKM-RPPKKEGQPTIVYFHVTVMGLDSI 67

  Fly    65 NLKNQIMTTNVWVEQEWNDYKLK--------------------WNPDDY------GGVDTLHVPS 103
            :..:.....:|:..|.|.|::|:                    |.||.:      ....|:.:|:
  Fly    68 DENSMTYVADVFFAQTWKDHRLRLPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPN 132

  Fly   104 EHIWL--PDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMK 166
            .::||  ...:||           |.|..|              |..|.::...:|.|.|.|.::
  Fly   133 HYMWLYKDKTILY-----------MVKLTL--------------KLSCIMNFAIYPHDTQECKLQ 172

  Fly   167 FGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWD------------IMRVPAVRNE-- 217
            ..|            |..|.|.             :..:||            :.:|..:|||
  Fly   173 MES------------LSHTTDD-------------LIFQWDPTTPLVVDENIELPQVALIRNETA 212

  Fly   218 ---KFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYL-PSDSGEKISLCISI 278
               :.||......|::||  ||:|:.::|..|..||...|..:|.:.|:: |..:..:::|.::.
  Fly   213 DCTQVYSTGNFTCLEVVF--TLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTS 275

  Fly   279 LLSLTVFFLLLAEIIPPTSLTVPLLGKYL-----------LFTMMLVTLSVVVTIAVLNVNFRSP 332
            ||:|:.........:||.|        ||           :|..|.:....::.|.:.:.....|
  Fly   276 LLTLSTQHAKSQSSLPPVS--------YLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPIPKP 332

  Fly   333 VTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPP 369
            :.:.             ||.:..:.||||  .|..||
  Fly   333 MAYP-------------PKPVAGDGPKKE--GEGAPP 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	49/262 (19%)
		LIC	27..530	CDD:455710	78/400 (20%)
		Cys-loop	149..163	CDD:349832	4/13 (31%)
ort	NP_524406.1	LIC	31..481	CDD:455710	79/403 (20%)
		LGIC_ECD_HisCl	51..235	CDD:349793	42/235 (18%)
		Cys-loop	155..169	CDD:349793	4/13 (31%)